Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350000, China.
College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, China.
J Mech Behav Biomed Mater. 2023 Sep;145:105979. doi: 10.1016/j.jmbbm.2023.105979. Epub 2023 Jul 6.
The carbon fiber reinforced polyetheretherketone (CFR-PEEK) has been increasingly used in orthopedics dentistry due to its excellent biocompatibility and mechanical properties. However, the biological inertness and poor antibacterial activity limit its clinical applications. This paper focused on the performances of CFR-PEEK with porous morphology that were exposed to different sulfonation periods (1, 3, 5, and 10 min, corresponding to CP-S1, CP-S3, CP-S5, and CP-S10, respectively). Residual sulfuric acid was removed by acetone rinsing, NaOH immersion, and hydrothermal treatment before in vitro and in vivo studies. The results showed some significant difference in the physicochemical properties, including energy dispersive X-ray spectroscopy (EDS) map of sulfur atoms, X-ray photoelectron spectroscopy (XPS) of valences of sulfur ions, Fourier transformation infrared spectroscopy (FTIR), hydrophilicity, hardness, and elastic modulus among CP-S3, CP-S5, and CP-S10. However, CP-S5 and CP-S10 were more effective in promoting the proliferation, adhesion, and osteogenic differentiation of seeded bone mesenchymal stem cells (BMSCs) and growth inhibition of S. aureus and P. gingivalis compared with other groups. Furthermore, the CP-S5 and CP-S10 samples achieved better cranial bone repair than the non-sulfonation group in a rat model. Therefore, it can be inferred that both 5 and 10 min are viable sulfonation durations for 30% CFR-PEEK. These findings provide a theoretical basis for developing CFR-PEEK for clinical applications.
碳纤维增强聚醚醚酮（CFR-PEEK）由于其优异的生物相容性和机械性能，在矫形牙科领域的应用越来越多。然而，其生物惰性和较差的抗菌活性限制了其临床应用。本文主要研究了具有多孔形态的 CFR-PEEK 的性能，这些 CFR-PEEK 分别经过 1、3、5 和 10 min（分别对应 CP-S1、CP-S3、CP-S5 和 CP-S10）的磺化处理。在进行体外和体内研究之前，通过丙酮冲洗、NaOH 浸泡和水热处理去除残留的硫酸。结果表明，在物理化学性质方面存在一些显著差异，包括硫原子的能谱（EDS）图谱、硫离子价态的 X 射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）、亲水性、硬度和弹性模量等，其中 CP-S3、CP-S5 和 CP-S10 之间存在差异。然而，与其他组相比，CP-S5 和 CP-S10 更能有效促进种子骨髓间充质干细胞（BMSCs）的增殖、黏附和成骨分化，以及抑制金黄色葡萄球菌和牙龈卟啉单胞菌的生长。此外，CP-S5 和 CP-S10 样品在大鼠模型中比非磺化组更能有效修复颅骨。因此，可以推断对于 30% CFR-PEEK，磺化时间为 5 分钟和 10 分钟都是可行的。这些发现为开发用于临床应用的 CFR-PEEK 提供了理论依据。
