State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
Biomaterials. 2014 Jul;35(22):5731-40. doi: 10.1016/j.biomaterials.2014.04.003. Epub 2014 Apr 22.
As an implantable material, carbon-fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to that of cortical bone and is a prime candidate to replace metallic surgical implants. However, the bioinertness and poor osteogenic properties of CFRPEEK limit its clinical application as orthopedic implants. In this work, titanium ions are introduced energetically into CFRPEEK by plasma immersion ion implantation (PIII). Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) reveal the formation of nanopores with the side wall and bottom embedded with ∼20 nm TiO2 nanoparticles on the CFRPEEK surface. Nanoindentation measurements confirm the stability and improved elastic resistance of the structured surfaces. In vitro cell adhesion, viability assay, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteo-differentiation of rat bone mesenchymal stem cells (bMSCs). The multilevel structures on CFRPEEK also exhibit partial antibacterial activity to Staphylococcus aureus and Escherichia coli. Our results indicate that a surface with multifunctional biological properties can be produced by multilevel surface engineering and application of CFRPEEK to orthopedic and dental implants can be broadened and expedited based on this scheme.
作为一种可植入材料，碳纤维增强聚醚醚酮（CFRPEEK）具有类似于皮质骨的可调节弹性模量，是替代金属外科植入物的首选材料。然而，CFRPEEK 的生物惰性和较差的成骨性能限制了其作为骨科植入物的临床应用。在这项工作中，通过等离子体浸没离子注入（PIII）将钛离子有效地引入 CFRPEEK。扫描电子显微镜（SEM）和 X 射线光电子能谱（XPS）揭示了 CFRPEEK 表面形成了纳米孔，其侧壁和底部嵌入了约 20nm 的 TiO2 纳米颗粒。纳米压痕测量证实了结构化表面的稳定性和弹性阻力的提高。体外细胞黏附、活力测定和实时 PCR 分析表明，大鼠骨髓间充质干细胞（bMSCs）的黏附、增殖和成骨分化得到增强。CFRPEEK 的多级结构对金黄色葡萄球菌和大肠杆菌也表现出部分抗菌活性。我们的结果表明，通过多级表面工程可以产生具有多功能生物特性的表面，并且可以根据该方案拓宽和加速 CFRPEEK 在骨科和牙科植入物中的应用。
