松弛素对人类精子的影响。

Effect of relaxin on human spermatozoa.

作者信息

Lessing J B, Brenner S H, Colon J M, Ginsburg F W, Schoenfeld C, Goldsmith L T, Sarosi P, Amelar R D, Dubin L, Weiss G

出版信息

J Reprod Med. 1986 May;31(5):304-9.

Abstract

To study its effect on the motility of human spermatozoa, relaxin was added at different concentrations to human semen samples of various qualities as well as to washed spermatozoa. Relaxin in physiologic concentrations (10-100 ng/mL) had no significant effect on sperm motility in normal semen samples. However, the addition of relaxin to semen samples with low sperm motility significantly increased the motility. Addition of relaxin similarly increased the motility of spermatozoa from normal semen samples that were either aged or washed; the treatment resulted in a decrease in motility. When sperm motility was optimal, as in normal samples, addition of relaxin did not increase motility. However, in some situations of decreased motility, addition of relaxin resulted in improvement of spermatozoan motility. Relaxin may have clinical value in the treatment of male infertility.

摘要

为研究松弛素对人类精子活力的影响，将不同浓度的松弛素添加到各种质量的人类精液样本以及洗涤后的精子中。生理浓度（10 - 100 ng/mL）的松弛素对正常精液样本中的精子活力无显著影响。然而，向精子活力低的精液样本中添加松弛素可显著提高活力。向老化或洗涤后的正常精液样本中的精子添加松弛素同样可提高活力；但该处理会导致活力下降。当精子活力处于最佳状态时，如在正常样本中，添加松弛素不会提高活力。然而，在一些活力下降的情况下，添加松弛素可改善精子活力。松弛素在男性不育症治疗中可能具有临床价值。