一项初步研究：探究 COVID-19 对心血管生理学和视网膜微循环的影响。

A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation.

机构信息

Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Austria; Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, Lillehammer, Norway.

Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Austria.

出版信息

Microvasc Res. 2023 Nov;150:104588. doi: 10.1016/j.mvr.2023.104588. Epub 2023 Jul 17.

DOI:10.1016/j.mvr.2023.104588

PMID:37468091

Abstract

BACKGROUND

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the cardiovascular system. The current study investigated changes in heart rate (HR), blood pressure (BP), pulse wave velocity (PWV), and microcirculation in patients recovering from Coronavirus disease 2019 (COVID-19) infection.

METHODOLOGY

Out of 43 initially contacted COVID-19 patients, 35 (30 males, 5 females; age: 60 ± 10 years; and body mass index (BMI): 31.8 ± 4.9) participated in this study. Participants were seen on two occasions after hospital discharge; the baseline measurements were collected, either on the day of hospital discharge if a negative PCR test was obtained, or on the 10th day after hospitalization if the PCR test was positive. The second measurements were done 60 days after hospitalization. The vascular measurements were performed using the VICORDER® device and a retinal blood vessel image analysis.

RESULTS

A significant increase in systolic BP (SBP) (from 142 mmHg, SD: 15, to 150 mmHg, SD: 19, p = 0.041), reduction in HR (from 76 bpm, SD: 15, to 69 bpm, SD: 11, p = 0.001), and narrower central retinal vein equivalent (CRVE) (from 240.94 μm, SD: 16.05, to 198.05 μm, SD: 17.36, p = 0.013) were found. Furthermore, the trends of increasing PWV (from 11 m/s, SD: 3, to 12 m/s, SD: 3, p = 0.095) and decreasing CRAE (from 138.87 μm, SD: 12.19, to 136.77 μm, SD: 13.19, p = 0.068) were recorded.

CONCLUSION

The present study investigated cardiovascular changes following COVID-19 infection at two-time points after hospital discharge (baseline measurements and 60 days post-hospitalization). Significant changes were found in systolic blood pressure, heart rate, and microvasculature indicating that vascular adaptations may be ongoing even weeks after hospitalization from COVID-19 infection. Future studies could involve conducting additional interim assessments during the active infection and post-infection periods.

摘要

背景

严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）会影响心血管系统。本研究调查了新冠肺炎（COVID-19）感染康复患者的心率（HR）、血压（BP）、脉搏波速度（PWV）和微循环的变化。

方法

在最初联系的 43 名 COVID-19 患者中，有 35 名（30 名男性，5 名女性；年龄：60±10 岁；体重指数（BMI）：31.8±4.9）参与了这项研究。参与者在出院后两次就诊时接受检查；收集基线测量值，如果获得阴性 PCR 检测结果，则在出院当天进行，如果 PCR 检测结果为阳性，则在住院后第 10 天进行。第二次测量是在住院后 60 天进行的。血管测量使用 VICORDER®设备和视网膜血管图像分析进行。

结果

发现收缩压（SBP）显著升高（从 142mmHg，SD：15，到 150mmHg，SD：19，p=0.041），心率（从 76bpm，SD：15，到 69bpm，SD：11，p=0.001）降低，中央视网膜静脉当量（CRVE）变窄（从 240.94μm，SD：16.05，到 198.05μm，SD：17.36，p=0.013）。此外，还记录到 PWV 呈上升趋势（从 11m/s，SD：3，到 12m/s，SD：3，p=0.095）和 CRAE 降低（从 138.87μm，SD：12.19，到 136.77μm，SD：13.19，p=0.068）。