Weir F W
J Occup Med. 1979 Apr;21(4):281-4.
Continuing interest by OSHA-NIOSH and by EPA regarding the adequacy of current sulfur oxides standards has prompted a reappraisal of the available human and animal data. Results of animals studies were not considered to be useful in establishing the original air quality standards in 1970, even though there was good reason to consider them as a prime source of information. Considering the multitude of species tested, using every conceivable method of administration and range of doses, a fairly consistent pattern of effect has emerged. Further, the majority of the human clinical data and even the industrial data parallel and support the results found in the animal studies. However, neither the animal studies, the clinical investigations nor the industrial experiences agree with the recently reported community epidemiological studies that are currently receiving attention. It may well be that the toxicological data are correct in that there are no important long-term effects from exposure to the sulfur oxides. Certainly the laboratory studies, animal or human, do not support more stringent standards for either the occupational or the community environment.
美国职业安全与健康管理局（OSHA）-美国国家职业安全卫生研究所（NIOSH）以及美国环境保护局（EPA）对当前二氧化硫标准是否充分持续保持关注，这促使人们重新评估现有的人类和动物数据。尽管有充分理由将动物研究结果视为主要信息来源，但在1970年制定最初的空气质量标准时，动物研究结果并未被认为有用。考虑到测试的物种众多，使用了各种可想象的给药方法和剂量范围，已出现了相当一致的效应模式。此外，大多数人类临床数据甚至工业数据都与动物研究结果相似并提供了支持。然而，动物研究、临床调查以及工业经验均与最近受到关注的社区流行病学研究结果不一致。很可能毒理学数据是正确的，即接触二氧化硫不会产生重要的长期影响。当然，无论是动物还是人类的实验室研究，都不支持针对职业或社区环境制定更严格的标准。
