Sultan Qiret, Massey Blaine, Cotter David G
Department of Internal Medicine, Kirk Kerkorian School of Medicine at University of Nevada, Las Vegas, Las Vegas, USA.
Department of Dermatology, Las Vegas Dermatology, Las Vegas, USA.
Cureus. 2023 Jun 17;15(6):e40582. doi: 10.7759/cureus.40582. eCollection 2023 Jun.
Disseminated superficial actinic porokeratosis (DSAP) is a disorder of abnormal keratinization for which there is no standard treatment. Treatment modalities that have traditionally been utilized with varying success include ablative therapies, topical pharmacologic treatments, surgical excision, and retinoids. The underlying pathophysiology of DSAP is secondary to genetic mutations in the mevalonate biosynthesis pathway, and thus topical lovastatin/cholesterol presents a promising treatment modality for this condition. We present a case of familial DSAP successfully treated with topical lovastatin/cholesterol gel and provide a brief review of the existing literature surrounding this novel therapy.
播散性浅表性光化性汗孔角化症（DSAP）是一种异常角化疾病，目前尚无标准治疗方法。传统上使用的治疗方式效果各异，包括消融疗法、局部药物治疗、手术切除和维甲酸类药物。DSAP的潜在病理生理学继发于甲羟戊酸生物合成途径中的基因突变，因此局部使用洛伐他汀/胆固醇为这种疾病提供了一种有前景的治疗方式。我们报告一例成功使用局部洛伐他汀/胆固醇凝胶治疗的家族性DSAP病例，并简要回顾围绕这种新疗法的现有文献。
