Wang Yingying, Ye Xing, Song Bo, Yan Yixin, Ma Wenyin, Shi Jingping
Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Front Neurosci. 2023 Jul 4;17:1185228. doi: 10.3389/fnins.2023.1185228. eCollection 2023.
To provide a rigorous comparison between patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD) and healthy elderly, as well as to assess the value of electroencephalography (EEG) in terms of early diagnosis, we conducted a neutral image recognition memory task involving individuals with positive biomarkers including β amyloid deposition, pathologic tau or neurodegeneration.
The task involving study and test blocks was designed to evaluate participants' recognition memory. Electroencephalogram was recorded synchronously to elicit event-related potentials in patients with MCI-AD and healthy control subjects. We further analyzed differences between groups or conditions in terms of behavioral performance, time domain, and time-frequency domain.
The MCI-AD cohort showed a slower response time to old/new images and had low accuracy regarding behavioral performance. The amplitude of the late positive complex for the old/new effects was significantly suppressed in the MCI-AD cohort when compared with that in the HC cohort. The amplitude of the late old/new effects was correlated with the Auditory Verbal Learning Test recognition score in all participants. The time-frequency domain analysis revealed that correct recognition of old items elicited a decrease in beta power, mainly limited to the HC cohort. Moreover, the combination of behavioral (processing speed and accuracy) and electrophysiological (average amplitude and relative power of delta band) measures contributes to classifying patients with MCI-AD from healthy elderly people.
Changes of old/new effects, accuracy and response time are sensitive to the impairment of recognition memory in patients with MCI-AD and have moderate value in predicting the incipient stage of AD.
为了对阿尔茨海默病所致轻度认知障碍（MCI-AD）患者与健康老年人进行严格比较，并评估脑电图（EEG）在早期诊断方面的价值，我们对包括β淀粉样蛋白沉积、病理性tau或神经退行性变等生物标志物呈阳性的个体进行了中性图像识别记忆任务。
该任务包括学习和测试阶段，旨在评估参与者的识别记忆。同步记录MCI-AD患者和健康对照受试者的脑电图，以引出事件相关电位。我们进一步从行为表现、时域和时频域分析了组间或条件间的差异。
MCI-AD队列对旧/新图像的反应时间较慢，行为表现的准确性较低。与健康对照队列相比，MCI-AD队列中旧/新效应的晚期正复合波振幅显著受到抑制。在所有参与者中，晚期旧/新效应的振幅与听觉言语学习测试识别分数相关。时频域分析显示，正确识别旧项目会引起β功率降低，主要限于健康对照队列。此外，行为（处理速度和准确性）和电生理（δ频段的平均振幅和相对功率）测量的组合有助于将MCI-AD患者与健康老年人区分开来。
旧/新效应、准确性和反应时间的变化对MCI-AD患者的识别记忆损害敏感，在预测AD早期阶段具有中等价值。
