Li Jiarui, Zhang Xiaoying, Gesang Meiduo, Luo Benyan
Department of Neurology and Brain Medical Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Department of Neurology, Mental Health Center, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Heliyon. 2023 Apr 20;9(5):e15641. doi: 10.1016/j.heliyon.2023.e15641. eCollection 2023 May.
The aim of this study is to assess the central auditory processing (CAP) function and its electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) and the early stage of Alzheimer's disease (AD).
In this study, 25 patients with early AD, 22 patients with MCI, and 22 matched healthy controls (HC) were included. After cognitive assessment, binaural processing function was assessed using the staggered spondaic word (SSW) test, and auditory working memory was assessed by auditory n-back paradigm, while EEG was recorded. Patients' behavioral indicators, event-related potentials (ERPs) components, and function connection (FC) were compared between groups and the related factors were analyzed.
The difference of the accuracy of behavioral tests for the three groups of subjects was significant and all the behavioral indicators were positively correlated with cognitive function scores. Intergroup differences in amplitude ( < 0.05) and latency ( < 0.01) were significant for P3 in the 1-back paradigm. In the SSW test, AD and MCI patients showed reduced connectivity between the left frontal lobe and the whole brain in the δ-band, while in the n-back paradigm, patients with MCI and early AD showed reduced association of frontal leads with central and parietal leads in the δ-band.
Patients with MCI and early AD have reduced CAP functions including binaural processing function and auditory working memory functions. This reduction is significantly associated with reduced cognitive function, and is reflected in different patterns of changes in ERP as well as functional connectivity in the brain.
本研究旨在评估轻度认知障碍（MCI）和阿尔茨海默病（AD）早期患者的中枢听觉处理（CAP）功能及其脑电图（EEG）。
本研究纳入了25例早期AD患者、22例MCI患者和22例匹配的健康对照（HC）。在进行认知评估后，使用交错扬扬格词（SSW）测试评估双耳处理功能，通过听觉n-back范式评估听觉工作记忆，同时记录EEG。比较各组患者的行为指标、事件相关电位（ERP）成分和功能连接（FC），并分析相关因素。
三组受试者行为测试准确性的差异具有统计学意义，且所有行为指标均与认知功能评分呈正相关。在1-back范式中，P3的波幅（<0.05）和潜伏期（<0.01）组间差异具有统计学意义。在SSW测试中，AD和MCI患者在δ波段的左额叶与全脑之间的连接性降低，而在n-back范式中，MCI和早期AD患者在δ波段额叶导联与中央和顶叶导联之间的关联性降低。
MCI和早期AD患者的CAP功能降低，包括双耳处理功能和听觉工作记忆功能。这种降低与认知功能下降显著相关，并反映在ERP的不同变化模式以及大脑的功能连接中。
