Gibilisco P A, Lopez G A, Appleman M D, Millburg W J, Kushell D L, Elowitz L, Johnson P A, Zenowich D
JPEN J Parenter Enteral Nutr. 1986 Jul-Aug;10(4):431-4. doi: 10.1177/0148607186010004431.
Direct contact and airborne transmission are established modes of microbial contamination of standard intravenous (iv) assemblies such as piggyback and heparin lock. In this study, 60% of the standard iv assemblies inoculated with Staphylococcus aureus (S. aureus) at the barrel of their exposed needle grew these organisms when cultured in a Soy Casein Digest Broth (SCDB). Also, 40 closed, positive locking iv assemblies (Click-Lock) were inoculated at possible contamination sites, and none of these assemblies grew S. aureus in a SCDB. These in vitro studies suggest that a closed, positive locking iv assembly such as the Click-Lock device may substantially reduce, and potentially prevent contamination of iv systems.
直接接触和空气传播是标准静脉输液装置（如静脉滴注管和肝素锁）微生物污染的既定传播方式。在本研究中，60% 在暴露针头针筒处接种金黄色葡萄球菌的标准静脉输液装置，在酪蛋白大豆消化肉汤（SCDB）中培养时培养出了这些微生物。此外，在可能的污染部位对40个封闭的、带正向锁定功能的静脉输液装置（Click-Lock）进行接种，这些装置在SCDB中均未培养出金黄色葡萄球菌。这些体外研究表明，诸如Click-Lock装置之类的封闭、带正向锁定功能的静脉输液装置可能会大幅减少并有可能防止静脉输液系统受到污染。
