Indo T, Takahashi A
Jpn J Med. 1986 May;25(2):114-21. doi: 10.2169/internalmedicine1962.25.114.
L-Dopa was administered to 122 patients with Parkinson's disease over a time period up to 14 years. The results were summarized below. The akinesia and postural instability scores were significantly improved up to the 9th year. The rigidity and static tremor scores and the Parkinson score were significantly improved up to the 11th year. The Yahr stage was significantly improved up to the 8th year. The time course of Parkinson score was investigated in three groups, Yahr stage I/II group, Yahr stage III group, and Yahr stage IV/V group, taking into account the time interval between the onset of the disease and initiation of L-dopa therapy. No significant difference was found among the three groups. The above results suggested that the long-term prognosis of patients on L-dopa therapy in Japan was better than in Western countries. It was also though that L-dopa therapy should be instituted at the earliest possible stage of the disease.
在长达14年的时间里，对122例帕金森病患者使用了左旋多巴。结果总结如下。运动不能和姿势不稳评分在第9年之前有显著改善。强直和静止性震颤评分以及帕金森评分在第11年之前有显著改善。Yahr分期在第8年之前有显著改善。考虑到疾病发作与开始使用左旋多巴治疗之间的时间间隔，在Yahr分期I/II组、Yahr分期III组和Yahr分期IV/V组这三组中研究了帕金森评分的时间进程。三组之间未发现显著差异。上述结果表明，在日本接受左旋多巴治疗的患者的长期预后优于西方国家。还认为左旋多巴治疗应在疾病的最早阶段开始。
