Parati E A, Fetoni V, Geminiani G C, Soliveri P, Giovannini P, Testa D, Genitrini S, Caraceni T, Girotti F
Istituto Nazionale Neurologico C. Besta, Milan, Italy.
Clin Neuropharmacol. 1993 Apr;16(2):139-44. doi: 10.1097/00002826-199304000-00006.
A poor response to L-DOPA in addition to parkinsonian, cerebellar, and autonomic signs is commonly regarded as indicative of clinical multiple system atrophy (MSA). We compared the motor response to a single oral administration of 250 mg L-DOPA/25 mg carbidopa in eight MSA patients and eight Parkinson's disease (PD) patients with the "on-off" phenomenon, evaluating L-DOPA peripheral pharmacokinetics. Motor response was consistently good in all PD patients, but only four MSA patients had a (moderate) response. Pharmacokinetic parameters did not differ between the groups. The varying extent of putaminal damage could be responsible for the differing motor response to L-DOPA in MSA patients.
除帕金森氏症、小脑和自主神经体征外，对左旋多巴反应不佳通常被视为临床多系统萎缩（MSA）的指征。我们比较了8例MSA患者和8例有“开-关”现象的帕金森病（PD）患者单次口服250 mg左旋多巴/25 mg卡比多巴后的运动反应，并评估了左旋多巴的外周药代动力学。所有PD患者的运动反应始终良好，但只有4例MSA患者有（中度）反应。两组之间的药代动力学参数没有差异。壳核损伤程度的不同可能是MSA患者对左旋多巴运动反应不同的原因。
