Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Eur J Endocrinol. 2023 Jul 20;189(1):K1-K6. doi: 10.1093/ejendo/lvad093.
Sparse data are available on the etiology, morphology, clinical presentation, and outcomes of adrenal calcification. In this single-center retrospective study of 540 consecutive patients (median age 65 years, 45% women) with adrenal calcification on computed tomography (December 2017 to January 2021), most were discovered incidentally (472, 87%). The commonest etiology was idiopathic (389, 72%), followed by the adrenal tumor (113, 21%), hemorrhage (29, 5%), and infiltrative disease (7, 1%). Calcified adrenal tumors were predominantly benign (92, 81%) and primarily adenomas (63, 69%), whereas the most common calcified adrenal malignancy (16, 18%) was metastasis (12, 67%). Calcification (unilateral 94%, bilateral 6%) morphology varied from punctate (313, 58%) to coarse (165, 30%), linear/curvilinear (46, 9%), and rim-like (16, 3%). In summary, adrenal calcifications are usually incidentally discovered unilateral, punctate, or coarse lesions of unclear etiology. Most calcified adrenal tumors are benign and <20% malignant or pheochromocytomas.
关于肾上腺钙化的病因、形态、临床表现和转归，相关数据较为匮乏。本研究回顾性分析了 2017 年 12 月至 2021 年 1 月期间在我院就诊的 540 例 CT 检查发现肾上腺钙化的连续患者（中位年龄 65 岁，45%为女性），结果显示，472 例（87%）患者为偶然发现，最常见的病因是特发性（389 例，72%），其次是肾上腺肿瘤（113 例，21%）、出血（29 例，5%）和浸润性疾病（7 例，1%）。钙化性肾上腺肿瘤主要为良性（92 例，81%），且主要为腺瘤（63 例，69%），而最常见的钙化性肾上腺恶性肿瘤（16 例，18%）是转移瘤（12 例，67%）。钙化形态（单侧 94%，双侧 6%）从点状（313 例，58%）到粗糙（165 例，30%）、线状/曲线状（46 例，9%）和边缘状（16 例，3%）不等。总之，肾上腺钙化通常为单侧、偶然发现的点状或粗糙性、病因不明的病变。大多数钙化性肾上腺肿瘤为良性，恶性或嗜铬细胞瘤比例<20%。
