一项单病例观察：埃博拉病毒可溶性糖蛋白是否为病毒复发的指标？
A Single Case Observation: Is the Ebola Virus Soluble Glycoprotein an Indicator of Viral Recrudescence?
机构信息
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
出版信息
J Infect Dis. 2023 Nov 13;228(Suppl 7):S631-S634. doi: 10.1093/infdis/jiad279.
This case study investigated the long-term expression dynamics of Ebola virus (EBOV) soluble glycoprotein (sGP) in the serum of a patient who was infected with EBOV in West Africa and recovered from acute Ebola virus disease (EVD) at the National Institutes of Health Clinical Center in Bethesda, Maryland. Samples from this patient were collected during acute EVD and during convalescence up to day 361 following illness onset. Although blood samples were negative by reverse transcription-quantitative polymerase chain reaction after recovery from acute EVD, we detected small amounts of EBOV sGP in the serum of the patient long after recovery, potentially indicating viral recrudescence. As this was only observed in a single patient, additional longitudinal patient samples are needed to confirm our hypothesis that EBOV sGP may be an indicator of viral recrudescence long after recovery from acute EVD.
本病例研究调查了一位在马里兰州贝塞斯达市美国国立卫生研究院临床中心感染埃博拉病毒（EBOV）并从急性埃博拉病毒病（EVD）中康复的患者血清中 Ebola 病毒可溶性糖蛋白（sGP）的长期表达动态。该患者的样本在急性 EVD 期间和发病后 361 天的恢复期内采集。尽管患者从急性 EVD 康复后通过逆转录定量聚合酶链反应血液样本呈阴性，但我们在患者康复后很长一段时间内的血清中检测到少量的 EBOV sGP，这可能表明病毒复发。由于这仅在单个患者中观察到，因此需要更多的纵向患者样本来证实我们的假设，即 EBOV sGP 可能是急性 EVD 康复后很长一段时间内病毒复发的指标。
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