Department of Nursing, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
BMC Public Health. 2024 Feb 26;24(1):616. doi: 10.1186/s12889-024-18115-7.
Cardio-cerebrovascular diseases constitute a major global public health burden. Volatile organic compounds (VOCs) exposure has become progressively severe, endangering human health and becoming one of the main concerns in environmental pollution. The associations of VOCs exposure with nonfatal cardio-cerebrovascular events have not been identified in observational study with a large sample size, so we aim to examine the association in US adult population.
Adults aged > 18 years with complete data regarding selected blood levels of VOCs (including benzene, ethylbenzene, o-xylene, and m-/p-xylene) and nonfatal cardio-cerebrovascular events were included in the analysis (n = 3,968, National Health and Nutrition Examination Survey, NHANES, 2013-2018 survey cycle). Participants were classified into low- and high-exposure based on whether above selected VOCs low limit detect concentration or median value. Weighted multivariate logistic analyses and subgroup analyses were used to detect the association between selected VOCs exposure and nonfatal cardio-cerebrovascular events in US adults.
Weighted multivariate logistic analyses showed that the high-VOCs exposure group had an increased risk of nonfatal cardio-cerebrovascular events compared with the low-VOCs exposure group; the adjusted odds ratios (OR) and 95% confidence intervals (CI) of nonfatal cardio-cerebrovascular events for the high-VOCs exposure group were 1.41 (0.91, 2.19), 1.37 (0.96, 1.95), 1.32 (0.96, 1.82), and 1.17 (0.82, 1.67) for benzene, ethylbenzene, o-xylene, and m-/p-xylene, respectively, which was not significant assuming statistical significance at a 0.05 significance level (95% CI) for a two-tailed test. Lastly, we found high-VOCs exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in both daily smokers an non-daily smokers (p-interaction > 0.01), but the association was not statistically significant in non-daily smokers.
This study found that VOCs (benzene, ethylbenzene, o-xylene, and m-/p-xylene) exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in US adults, and the results need to be confirmed by larger cohort studies.
心脑血管疾病是全球主要的公共卫生负担之一。挥发性有机化合物（VOCs）暴露问题日益严重，危害着人类健康，成为环境污染的主要关注点之一。然而，在具有较大样本量的观察性研究中，尚未确定 VOCs 暴露与非致命性心脑血管事件之间的关联，因此，我们旨在检验美国成年人群中的这种关联。
本研究纳入了年龄大于 18 岁且具有完整的选定血液水平 VOCs（包括苯、乙苯、邻二甲苯和间/对二甲苯）和非致命性心脑血管事件数据的成年人（n=3968，美国国家健康和营养调查，NHANES，2013-2018 调查周期）。根据所选 VOCs 的低限检测浓度或中位数，参与者被分为低暴露组和高暴露组。使用加权多变量逻辑分析和亚组分析来检测美国成年人中选定 VOCs 暴露与非致命性心脑血管事件之间的关联。
加权多变量逻辑分析显示，与低 VOCs 暴露组相比，高 VOCs 暴露组发生非致命性心脑血管事件的风险增加；高 VOCs 暴露组非致命性心脑血管事件的调整后比值比（OR）和 95%置信区间（CI）分别为 1.41（0.91，2.19）、1.37（0.96，1.95）、1.32（0.96，1.82）和 1.17（0.82，1.67），苯、乙苯、邻二甲苯和间/对二甲苯分别如此，在双侧检验中，95%CI 不显著，假设统计显著性水平为 0.05（p<0.05）。最后，我们发现高 VOCs 暴露与非每日吸烟者和每日吸烟者的非致命性心脑血管事件发生率增加有关（p 交互作用>0.01），但在非每日吸烟者中，这种关联没有统计学意义。
本研究发现，美国成年人中 VOCs（苯、乙苯、邻二甲苯和间/对二甲苯）暴露与非致命性心脑血管事件的发生率增加有关，这一结果需要更大的队列研究来证实。
