Wang Yuanyuan, Han Xinhao, Li Jingkun, Zhang Liuchao, Liu Yu, Jin Ruifang, Chen Liang, Chu Xia
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, 150081, China.
Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin 150081, China.
Chemosphere. 2023 Jun;327:138425. doi: 10.1016/j.chemosphere.2023.138425. Epub 2023 Mar 15.
and Purpose Volatile organic compounds (VOCs) pose a serious respiratory hazard. This study evaluated the relationship between the compositional patterns of blood VOCs and the risk and age at onset of chronic respiratory diseases (CRDs), including asthma, emphysema and chronic bronchitis, with the objective of preventing or delaying CRDs.
Participants from five cycles of the NHANES survey were included. Blood VOCs were clustered using k-means clustering. Differences in VOCs and age at onset between multiple groups were compared with the Kruskal‒Wallis test. Logistic regression and a generalized linear model were applied to examine the associations between different compositional patterns of blood VOCs and risk and age at onset of CRDs.
12,386 participants were enrolled in this study. Three VOC compositional patterns were identified after clustering nine species of blood VOCs. The concentration of VOCs in pattern 2 was relatively low and stable. The concentrations of benzene, ethylbenzene, o-xylene, styrene, toluene and m-p-xylene in pattern 3 and the concentrations of 1,4-dichlorobenzene and MTBE in pattern 1 were significantly higher than those in pattern 2. After adjustment for covariates, the participants with VOC pattern 3 had an increased risk of asthma (OR = 1.23, 95% CI: 1.02, 1.49), emphysema (OR = 3.37, 95% CI: 2.24, 5.06) and chronic bronchitis (OR = 1.79, 95% CI: 1.30, 2.45). Meanwhile, VOC pattern 3 was negatively correlated with the age at onset of asthma (β = -5.61, 95% CI: 9.69, -1.52) and chronic bronchitis (β = -9.17, 95% CI: 13.96, -4.39). VOC pattern 1 was not associated with either risk or age at onset of the three CRDs after adjustment.
Changing the compositional pattern of blood VOCs by reducing certain species of VOCs may be a new strategy to lengthen the ages at onset of CRDs and effectively prevent them.
挥发性有机化合物（VOCs）对呼吸系统构成严重危害。本研究评估了血液中挥发性有机化合物的组成模式与慢性呼吸道疾病（CRDs）（包括哮喘、肺气肿和慢性支气管炎）的发病风险及发病年龄之间的关系，旨在预防或延缓慢性呼吸道疾病的发生。
纳入了美国国家健康与营养检查调查（NHANES）五个周期的参与者。使用k均值聚类法对血液中的挥发性有机化合物进行聚类。采用Kruskal-Wallis检验比较多组之间挥发性有机化合物和发病年龄的差异。应用逻辑回归和广义线性模型来检验血液中挥发性有机化合物的不同组成模式与慢性呼吸道疾病的发病风险及发病年龄之间的关联。
本研究共纳入12386名参与者。对9种血液挥发性有机化合物进行聚类后，确定了3种挥发性有机化合物组成模式。模式2中挥发性有机化合物的浓度相对较低且稳定。模式3中苯、乙苯、邻二甲苯、苯乙烯、甲苯和间对二甲苯的浓度以及模式1中1,4-二氯苯和甲基叔丁基醚的浓度均显著高于模式2。在调整协变量后，挥发性有机化合物模式3的参与者患哮喘（比值比[OR]=1.23，95%置信区间[CI]：1.02，1.49）、肺气肿（OR=3.37，95%CI：2.24，5.06）和慢性支气管炎（OR=1.79，95%CI：1.30，2.45）的风险增加。同时，挥发性有机化合物模式3与哮喘（β=-5.61，95%CI：9.69，-1.52）和慢性支气管炎（β=-9.17，95%CI：13.96，-4.39）的发病年龄呈负相关。调整后，挥发性有机化合物模式1与三种慢性呼吸道疾病的发病风险或发病年龄均无关联。
通过减少某些种类的挥发性有机化合物来改变血液中挥发性有机化合物的组成模式，可能是延长慢性呼吸道疾病发病年龄并有效预防这些疾病的一种新策略。
