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双重抗原递呈显示出良好的前景。

Dual delivery of antigens shows promise.

机构信息

Department of Analytical Chemistry, School of Chemistry, Universidad Complutense of Madrid, Madrid, Spain.

Department of Preventive Medicine, Public Health and Microbiology, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.

出版信息

Elife. 2023 Jul 21;12:e90407. doi: 10.7554/eLife.90407.

DOI:10.7554/eLife.90407
PMID:37477291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10361713/
Abstract

The simultaneous delivery of protein and lipid antigens via nanoparticles may help efforts to develop a new vaccine for tuberculosis.

摘要

纳米颗粒同时递送蛋白质和脂质抗原可能有助于开发结核病新型疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/10361713/5aff32ff96cb/elife-90407-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/10361713/5aff32ff96cb/elife-90407-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/10361713/5aff32ff96cb/elife-90407-fig1.jpg

相似文献

1
Dual delivery of antigens shows promise.双重抗原递呈显示出良好的前景。
Elife. 2023 Jul 21;12:e90407. doi: 10.7554/eLife.90407.
2
Induction of Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers.肺部递送载有分枝菌酸的聚合物胶束纳米载体诱导脂质特异性 T 细胞应答。
Front Immunol. 2018 Nov 27;9:2709. doi: 10.3389/fimmu.2018.02709. eCollection 2018.
3
Engineering Mycobacteria for the Production of Self-Assembling Biopolyesters Displaying Mycobacterial Antigens for Use as a Tuberculosis Vaccine.工程改造分枝杆菌以生产展示分枝杆菌抗原的自组装生物聚酯用作结核病疫苗。
Appl Environ Microbiol. 2017 Feb 15;83(5). doi: 10.1128/AEM.02289-16. Print 2017 Mar 1.
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A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.一种分枝菌酸特异性 CD1 限制性 T 细胞群体有助于人类结核感染的急性和记忆免疫应答。
J Clin Invest. 2011 Jun;121(6):2493-503. doi: 10.1172/JCI46216. Epub 2011 May 16.
5
CD1b-restricted GEM T cell responses are modulated by mycolic acid meromycolate chains.CD1b 限制性 GEM T 细胞反应受类脂阿拉伯甘露糖脂的酰基链调节。
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10956-E10964. doi: 10.1073/pnas.1708252114. Epub 2017 Nov 20.
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Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis.分枝菌酸，一种有前途的分枝杆菌配体，可用于靶向结核分枝杆菌纳米囊泡药物。
J Control Release. 2015 Aug 10;211:94-104. doi: 10.1016/j.jconrel.2015.06.005. Epub 2015 Jun 6.
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Synthesis and biological aspects of mycolic acids: an important target against Mycobacterium tuberculosis.分枝菌酸的合成及生物学特性：抗结核分枝杆菌的重要靶点
ScientificWorldJournal. 2008 Jul 31;8:720-51. doi: 10.1100/tsw.2008.99.
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[Significance of certain lipids of Mycobacterium tuberculosis (literature review)].[结核分枝杆菌某些脂质的意义（文献综述）]
Probl Tuberk. 1974(1):59-62.
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CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.CD1b-分枝菌酸四聚体显示出对分枝杆菌脂质尾部的T细胞精细特异性。
Eur J Immunol. 2017 Sep;47(9):1525-1534. doi: 10.1002/eji.201747062. Epub 2017 Jul 31.
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Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.两种辅助蛋白调控分枝杆菌 MmpL3 类脂酰载体蛋白的转运。
mBio. 2019 Jun 25;10(3):e00850-19. doi: 10.1128/mBio.00850-19.

本文引用的文献

1
Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells.分枝杆菌脂质负载纳米颗粒疫苗接种导致脂质抗原持续存在，并使抗原特异性 T 细胞分化为记忆细胞。
Elife. 2023 Oct 25;12:RP87431. doi: 10.7554/eLife.87431.
2
Induction of Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers.肺部递送载有分枝菌酸的聚合物胶束纳米载体诱导脂质特异性 T 细胞应答。
Front Immunol. 2018 Nov 27;9:2709. doi: 10.3389/fimmu.2018.02709. eCollection 2018.
3
Benchmarking Bicontinuous Nanospheres against Polymersomes for in Vivo Biodistribution and Dual Intracellular Delivery of Lipophilic and Water-Soluble Payloads.
对体内生物分布和脂溶性及亲水性载物双重细胞内递药的双连续纳米球与聚合物囊泡进行基准测试。
ACS Appl Mater Interfaces. 2018 Oct 10;10(40):33857-33866. doi: 10.1021/acsami.8b09906. Epub 2018 Sep 27.
4
Tuberculosis: Just the FAQs.结核病：常见问题解答。
mBio. 2017 Dec 19;8(6):e01910-17. doi: 10.1128/mBio.01910-17.
5
Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis.脂质抗原疫苗在豚鼠结核病模型中的保护效力
Vaccine. 2017 Mar 7;35(10):1395-1402. doi: 10.1016/j.vaccine.2017.01.079. Epub 2017 Feb 9.
6
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model.在人源化转基因小鼠模型中，分枝菌酸特异性T细胞可预防结核分枝杆菌感染。
Elife. 2015 Dec 10;4:e08525. doi: 10.7554/eLife.08525.
7
Vaccine delivery carriers: insights and future perspectives.疫苗递送载体：研究进展与未来展望。
Int J Pharm. 2013 Jan 2;440(1):27-38. doi: 10.1016/j.ijpharm.2012.04.047. Epub 2012 Apr 23.
8
Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness.卡介苗接种对全球儿童结核性脑膜炎和粟粒性肺结核的影响：一项荟萃分析及成本效益评估
Lancet. 2006 Apr 8;367(9517):1173-80. doi: 10.1016/S0140-6736(06)68507-3.
9
Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.用分枝杆菌脂质疫苗进行免疫可改善豚鼠结核病模型中的肺部病理状况。
Int Immunol. 2003 Aug;15(8):915-25. doi: 10.1093/intimm/dxg091.