MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK.
UK Centre for Ecology & Hydrology, Wallingford, Oxfordshire, UK.
Sci Adv. 2023 Jul 21;9(29):eadh8839. doi: 10.1126/sciadv.adh8839.
Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, , that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant to reduce treatment failure in patients with aspergillosis.
利用公民科学方法，我们发现一种人类真菌病原体（）的气溶胶化孢子在全国范围内暴露，这种病原体已经对农业杀真菌剂戊唑醇和一线唑类临床抗真菌药物产生了耐药性。基因组分析表明，在环境中和患者中发现的耐药基因型之间没有区别，这表明至少 40%的唑类耐药感染是从环境暴露中获得的。气溶胶化唑类耐药孢子的热点和冷点在季节性采样期间并不稳定。这表明大气混合程度很高，估计人均每年累计暴露时间为 21 天（±2.6）。由于这种测量暴露的普遍性，我们必须确定唑类耐药的来源，以减少曲霉菌病患者的治疗失败。
