甲状旁腺激素与新生儿钙稳态：亚洲新生儿继发性甲状旁腺功能亢进的证据。

Parathyroid hormone and neonatal calcium homeostasis: evidence for secondary hyperparathyroidism in the Asian neonate.

作者信息

Okonofua F, Menon R K, Houlder S, Thomas M, Robinson D, O'Brien S, Dandona P

出版信息

Metabolism. 1986 Sep;35(9):803-6. doi: 10.1016/0026-0495(86)90219-2.

Abstract

Calcium, 25-hydroxyvitamin D (25 OHD), and parathyroid hormone (PTH) concentrations were measured in 11 Asian and ten Caucasian pregnant women at parturition and in their respective newborns following a full term normal delivery. Maternal calcium and 25 OHD concentrations were significantly lower while PTH concentrations were significantly greater in Asians than those in Caucasians. There was a significant inverse relationship between calcium and PTH and the relationship between 25 OHD and PTH concentrations. Neonatal calcium and 25 OHD concentrations were also significantly lower and PTH concentrations significantly higher in Asians than those in Caucasians. There was a highly significant inverse correlation between neonatal calcium and PTH concentrations. Three of the 11 Asian babies had supranormal concentrations of PTH in their cord blood. We conclude that PTH participates in neonatal calcium homeostasis and Asian newborns have frequent secondary hyperparathyroidism.

摘要

对11名亚洲孕妇和10名高加索孕妇在分娩时及其足月正常分娩后的各自新生儿进行了钙、25-羟维生素D（25OHD）和甲状旁腺激素（PTH）浓度的测定。亚洲孕妇的钙和25OHD浓度显著低于高加索孕妇，而PTH浓度显著高于高加索孕妇。钙与PTH之间以及25OHD与PTH浓度之间存在显著的负相关关系。亚洲新生儿的钙和25OHD浓度也显著低于高加索新生儿，PTH浓度显著高于高加索新生儿。新生儿钙与PTH浓度之间存在高度显著的负相关。11名亚洲婴儿中有3名脐带血中PTH浓度超常。我们得出结论，PTH参与新生儿钙稳态的维持，亚洲新生儿常有继发性甲状旁腺功能亢进。