Mastromarino P, Conti C, Orsi N
Microbiologica. 1986 Jul;9(3):295-303.
The role of mannose containing molecules in Sindbis virus envelope glycoproteins and cell membrane receptors was investigated by means of concanavalin A (con A). Treatment of virus or BHK 21 cells with the lectin before infection reduced viral infectivity. Hemagglutination and hemolysis showed a different sensitivity to con A. Hemagglutination was not affected by the lectin and treatment of erythrocytes with con A produced an enhancement of agglutinability by the virus. Hemolytic activity was, on the contrary, strongly reduced by the lectin. The inhibition observed is due to an action on viral structures and not to an interaction with erythrocyte receptors because con A did not affect the hemolysis when preincubated with erythrocytes.
通过伴刀豆球蛋白A（Con A）研究了含甘露糖分子在辛德毕斯病毒包膜糖蛋白和细胞膜受体中的作用。在感染前用凝集素处理病毒或BHK 21细胞可降低病毒感染性。血凝和溶血对Con A表现出不同的敏感性。血凝不受凝集素影响，用Con A处理红细胞可增强病毒的凝集能力。相反，凝集素可强烈降低溶血活性。观察到的抑制作用是由于对病毒结构的作用，而非与红细胞受体的相互作用，因为Con A与红细胞预孵育时不影响溶血。
