Department of Evolutionary Biology, Ecology and Environmental Sciences, University of Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Institute of Health Carlos III, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain.
Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Institute of Health Carlos III, Spain; Department of Epidemiology, University of Florida, United States.
Front Neuroendocrinol. 2023 Oct;71:101083. doi: 10.1016/j.yfrne.2023.101083. Epub 2023 Jul 19.
Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor.
黏膜分泌型免疫球蛋白 A（s-IgA）已被认为是人体抵抗感染的第一道防线的关键组成部分。然而，其对心理社会应激源的反应仍知之甚少。本系统评价旨在探讨 18 岁以下人群在经历心理社会应激后 s-IgA 水平是否发生变化。共纳入 15 篇文章。暴露于应激下的 9 岁以上儿童 s-IgA 基础水平升高。此外，s-IgA 似乎存在昼夜节律，在应激条件下发生改变。最后，综合证据表明，青春期后急性应激下唾液 s-IgA 迅速增加。总的来说，本综述表明 s-IgA 可被视为儿科和儿童青少年精神病学人群潜在的心理社会应激生物标志物。需要进一步的研究来验证 s-IgA 昼夜节律和基础水平作为心理社会应激生物标志物的作用，并阐明年龄和应激类型的作用。
