IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea.
Global Medical Research Center, Seoul 03737, Republic of Korea.
Nutrients. 2024 Apr 29;16(9):1339. doi: 10.3390/nu16091339.
Heat-treated nF1 (HT-nF1) increases immune cell activation and the production of various immunomodulators (e.g., interleukin (IL)-12) as well as immunoglobulin (Ig) G, which plays an important role in humoral immunity, and IgA, which activates mucosal immunity. To determine the effect of HT-nF1 intake on improving immune function, a randomized, double-blind, placebo-controlled study was conducted on 100 subjects with normal white blood cell counts. The HT-nF1 group was administered capsules containing 5 × 10 cells of HT-nF1 once a day for 8 weeks. After 8 weeks of HT-nF1 intake, significant changes in IL-12 were observed in the HT-nF1 group ( = 0.045). In particular, the change in natural killer (NK) cell activity significantly increased in subjects with low secretory (s) IgA (≤49.61 μg/mL) and low NK activity (E:T = 10:1) (≤3.59%). These results suggest that HT-nF1 has no safety issues and improves the innate immune function by regulating T helper (Th)1-related immune factors. Therefore, we confirmed that HT-nF1 not only has a positive effect on regulating the body's immunity, but it is also a safe material for the human body, which confirms its potential as a functional health food ingredient.
热处理 nF1（HT-nF1）可增强免疫细胞的激活作用，并产生各种免疫调节剂（如白细胞介素（IL）-12）以及免疫球蛋白（Ig）G，后者在体液免疫中起重要作用，IgA 则激活黏膜免疫。为了确定摄入 HT-nF1 对改善免疫功能的影响，对 100 名白细胞计数正常的受试者进行了一项随机、双盲、安慰剂对照研究。HT-nF1 组每天服用含有 5×10 个 HT-nF1 细胞的胶囊一次，持续 8 周。在摄入 HT-nF1 8 周后，HT-nF1 组的 IL-12 发生了显著变化（=0.045）。特别是，在 sIgA（≤49.61μg/mL）和 NK 活性低（E:T=10:1）（≤3.59%）的受试者中，NK 细胞活性的变化显著增加。这些结果表明，HT-nF1 不存在安全问题，通过调节辅助性 T 细胞（Th）1 相关免疫因子来改善固有免疫功能。因此，我们证实 HT-nF1 不仅对调节机体免疫力具有积极作用，而且对人体也是一种安全的物质，这证实了其作为功能性保健食品成分的潜力。
