Rovira Aleix, Brunet Aina, Jeannon Jean Pierre, Carroll Paul V, Touska Phil, Hassan Fahim, Sandison Ann, Simo Ricard
Department of Otorhinolaryngology Head & Neck Surgery, Head, Neck and Thyroid Oncology Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
Department of Otorhinolaryngology Head & Neck Surgery, Head, Neck and Thyroid Oncology Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
Acta Otorrinolaringol Esp (Engl Ed). 2023 Jul-Aug;74(4):203-210. doi: 10.1016/j.otoeng.2023.03.007.
To review the clinical presentation, diagnosis, pathology and management strategies in a modern cohort of patients with thyroglossal duct cyst carcinoma.
Retrospective case series following PROCESS Guidelines.
Comprehensive cancer centre.
Data recorded included: gender, age at diagnosis, clinical presentation, thyroid function, diagnostic investigations, cytological results, final histology, staging and follow up status. The risk of malignancy in cytological analysis was stratified according to the Royal College of Pathologists classification in United Kingdom.
Twelve patients were included. The majority of patients (66.7%) presented with an isolated thyroglossal duct cyst. Only 4 patients had preoperative cytological suspicion of carcinoma (sensitivity: 33.3%). At the time of presentation all patients were euthyroid. Following diagnosis of malignancy, a total thyroidectomy was performed in all patients, with the exception of 2, who had a thyroglossal duct cyst carcinoma of less than 10mm. Among the 10 patients who underwent total thyroidectomy, 7 (70%) patients had proven carcinoma in the thyroid gland, 3 with deposits of less than 10mm. The average size of the thyroid cancer deposits was 7.2mm (1-20mm). With a mean follow-up of is 44 months (5-120), all patients were alive and free of recurrence at the end of the study period.
Thyroglossal duct cyst carcinoma is a rare condition and its management should be discussed in a multidisciplinary meeting. As with differentiated thyroid cancer originating in the thyroid gland, it bears extraordinary survival rates. Accordingly, the management of these cancers has shifted towards a more conservative approach although its peculiarities must be taken into account: ease of extracystic invasion and possible different lymph node invasion.
回顾现代甲状腺舌管囊肿癌患者队列的临床表现、诊断、病理及管理策略。
遵循PROCESS指南的回顾性病例系列研究。
综合癌症中心。
记录的数据包括：性别、诊断时年龄、临床表现、甲状腺功能、诊断性检查、细胞学结果、最终组织学、分期及随访状态。根据英国皇家病理学家学会的分类对细胞学分析中的恶性风险进行分层。
纳入12例患者。大多数患者（66.7%）表现为孤立性甲状腺舌管囊肿。仅有4例患者术前细胞学怀疑为癌（敏感性：33.3%）。就诊时所有患者甲状腺功能正常。诊断为恶性肿瘤后，除2例甲状腺舌管囊肿癌小于10mm的患者外，所有患者均行甲状腺全切除术。在接受甲状腺全切除术的10例患者中，7例（70%）甲状腺内证实有癌，3例转移灶小于10mm。甲状腺癌转移灶的平均大小为7.2mm（1 - 20mm）。平均随访44个月（5 - 120个月），研究期末所有患者均存活且无复发。
甲状腺舌管囊肿癌是一种罕见疾病，其管理应在多学科会议上进行讨论。与起源于甲状腺的分化型甲状腺癌一样，其生存率极高。因此，这些癌症的管理已转向更保守的方法，尽管必须考虑其特殊性：易于囊外侵犯及可能不同的淋巴结侵犯。
