Molecular Imaging Center, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Molecular Imaging Center, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Adv Drug Deliv Rev. 2023 Sep;200:115020. doi: 10.1016/j.addr.2023.115020. Epub 2023 Jul 21.
Eukaryotic cell organelles sustain the life of cells. Their structural changes and dysfunctions can cause abnormal physiological activities and lead to various diseases. Molecular imaging technology enables the visualization of subcellular structures, cells, organs, and the whole living body's structure and metabolism dynamic changes. This could help to reveal the pharmacology mechanisms and drug delivery pathway in vivo. This article discusses the relationship between organelles and human disease, reviews recent probes targeting organelles and their behavior in vivo. We found that mitochondria-targeting probes prefer accumulation in the intestine, heart, and tumor. The lysosome-targeting probe accumulates in the intestine and tumor. Few studies on endoplasmic reticulum- or Golgi apparatus-targeting probes have been reported for in vivo imaging. We hope this review could provide new insights for developing and applying organelle-targeting probes.
真核细胞细胞器维持着细胞的生命活动。它们的结构变化和功能障碍会导致异常的生理活动，并导致各种疾病。分子成像技术能够可视化亚细胞结构、细胞、器官以及整个生物体的结构和代谢动态变化。这有助于揭示体内的药理学机制和药物传递途径。本文讨论了细胞器与人类疾病的关系，综述了近年来针对细胞器的探针及其在体内的行为。我们发现，线粒体靶向探针优先在肠道、心脏和肿瘤中积累。溶酶体靶向探针在肠道和肿瘤中积累。关于内质网或高尔基体靶向探针的体内成像研究较少。我们希望这篇综述能为开发和应用细胞器靶向探针提供新的思路。
