Indraprasit S, Ukaravichien V, Pummangura C, Kaojarern S
Nephron. 1986;44(1):18-21. doi: 10.1159/000183905.
Gentamicin removal during intermittent peritoneal dialysis was studied in 13 uremic patients. The peak serum level after 80 mg of gentamicin intravenous drip was 6.00 +/- 1.3 micrograms/ml with a serum half-life of 13.6 +/- 4.07 h. The gentamicin dialysate level did not correlate with the corresponding serum concentration. The peritoneal gentamicin clearance (10.0 +/- 3.65 ml/min) correlated with the rate of protein loss, but not with the peritoneal clearances of urea and creatinine. When 4% glucose dialysate was used, the clearance of the drug increased considerably along with the ultrafiltration rate. Adding gentamicin (5 micrograms/ml) to the dialysate resulted in a sustained serum drug level. The mechanism of gentamicin transport through the peritoneal membrane is discussed. The study demonstrated significant removal of gentamicin during intermittent peritoneal dialysis.
对13例尿毒症患者进行了间歇性腹膜透析过程中庆大霉素清除情况的研究。静脉滴注80mg庆大霉素后的血清峰值水平为6.00±1.3μg/ml，血清半衰期为13.6±4.07小时。庆大霉素透析液水平与相应的血清浓度无关。腹膜庆大霉素清除率（10.0±3.65ml/min）与蛋白质丢失率相关，但与尿素和肌酐的腹膜清除率无关。当使用4%葡萄糖透析液时，药物清除率随超滤率显著增加。向透析液中添加庆大霉素（5μg/ml）可使血清药物水平维持稳定。文中讨论了庆大霉素透过腹膜的转运机制。该研究表明间歇性腹膜透析过程中庆大霉素有显著清除。
