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亚胺连接的共价有机框架：一种用于阿霉素体外持续释放的生物相容性和pH依赖性载体。

Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin.

作者信息

Mokhtari Nazanin, Dinari Mohammad, Khosravi Esmaeiltarkhani Fatemeh

机构信息

Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran.

出版信息

ACS Omega. 2023 Jul 3;8(28):25565-25573. doi: 10.1021/acsomega.3c03316. eCollection 2023 Jul 18.

DOI:10.1021/acsomega.3c03316
PMID:37483239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357574/
Abstract

Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer cell line), respectively. It was observed that the APB-COF does not affect cell proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. Using APB-COF as the drug carrier can pave the way for using COFs in innovative DDSs.

摘要

在新型药物递送系统（DDSs）中，共价有机框架（COFs）在药学领域展现出了有前景的特性。本文在高压釜条件下合成了一种具有六边形拓扑结构的亚胺连接COF。然后，将制备的COF（APB-COF）用作阿霉素（DOX）体外释放的pH依赖性载体。APB-COF的固有特性使其达到了优异的药物包封效率。DOX@APB-COF在两种不同pH值下呈现出典型的pH依赖性释放。在pH = 7.4时，DOX的释放率为32%，将pH值改变为癌细胞的pH值（pH = 5.4）时，释放率增加到54%。此外，分别使用标准MTT试验研究了APB-COF和DOX@APB-COF对MCF10（正常乳腺细胞系）和MDAmb231细胞（乳腺癌细胞系）的细胞毒性。观察到APB-COF不影响细胞增殖，而DOX@APB-COF仅限制癌细胞增殖。使用APB-COF作为药物载体可为在创新型DDSs中使用COFs铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c9f411598b66/ao3c03316_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c0a939bef88b/ao3c03316_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c03d2b21054a/ao3c03316_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/ab601b0f5e9a/ao3c03316_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/f706b82abad0/ao3c03316_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/b99b3115f8e7/ao3c03316_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/9b8998456270/ao3c03316_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/2d2410145524/ao3c03316_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/e74c8b910b48/ao3c03316_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c9f411598b66/ao3c03316_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c0a939bef88b/ao3c03316_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c03d2b21054a/ao3c03316_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/ab601b0f5e9a/ao3c03316_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/f706b82abad0/ao3c03316_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/b99b3115f8e7/ao3c03316_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/9b8998456270/ao3c03316_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/2d2410145524/ao3c03316_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/e74c8b910b48/ao3c03316_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576e/10357574/c9f411598b66/ao3c03316_0009.jpg

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引用本文的文献

[1]
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[2]
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本文引用的文献

[1]
Breast Cancer Statistics, 2022.

CA Cancer J Clin. 2022-11

[2]
Imine-Linked Covalent Organic Framework with a Naphthalene Moiety as a Sensitive Phosphate Ion Sensing.

ACS Appl Mater Interfaces. 2022-5-18

[3]
Synthesis of Chiral Covalent Organic Frameworks via Asymmetric Organocatalysis for Heterogeneous Asymmetric Catalysis.

Angew Chem Int Ed Engl. 2022-6-20

[4]
2D and 3D Covalent Organic Frameworks: Cutting-Edge Applications in Biomedical Sciences.

ACS Appl Bio Mater. 2022-1-17

[5]
Single-Phase Covalent Organic Framework Staggered Stacking Nanosheet Membrane for CO -Selective Separation.

Angew Chem Int Ed Engl. 2021-8-23

[6]
Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications.

Nanomicro Lett. 2020-5-2

[7]
Advanced drug delivery applications of layered double hydroxide.

J Control Release. 2021-2-10

[8]
Optoelectronic processes in covalent organic frameworks.

Chem Soc Rev. 2021-2-15

[9]
Covalent Organic Frameworks for Heterogeneous Catalysis: Principle, Current Status, and Challenges.

ACS Cent Sci. 2020-6-24

[10]
Tumor therapy: targeted drug delivery systems.

J Mater Chem B. 2016-11-14

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