一锅法合成载多柔比星的共价有机框架，增强化疗疗效。
One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
University of Science and Technology of China, Hefei, 230026, P. R. China.
出版信息
Chemistry. 2019 Mar 21;25(17):4315-4319. doi: 10.1002/chem.201806242. Epub 2019 Mar 1.
Covalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time. The resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy.
共价有机框架（COFs）在多个研究领域引起了广泛关注。然而，文献中仅发现了少数关于 COFs 生物医学应用的报道。由于具有高度多孔和可调结构以及良好的热稳定性，COFs 作为化疗药物载体具有很大的潜力。在这项工作中，阿霉素（DOX）首次通过一锅法成功原位负载到 COF 中。所得的 DOX@COF 平台表现出高载药能力（32.1wt%）和 pH 响应性释放性能。体外和体内实验证明了其良好的生物相容性和增强的抗肿瘤功效。
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