Carter A L, Hartlage P L, Eller A G, Hommes F A
Neurology. 1986 Sep;36(9):1267-9. doi: 10.1212/wnl.36.9.1267.
Lactate, pyruvate, and glucose were determined in groups of 10 patients, each receiving single drug therapy for their seizure disorder with either phenytoin, valproic acid, carbamazepine, or phenobarbital, and in patients not taking medication. All drug levels were in their therapeutic ranges. The characteristics of the groups were similar, except for the phenytoin group being significantly older. No significant differences were found in glucose or pyruvate concentrations. However, patients on valproic acid had reduced lactate (p less than 0.05) and L/P ratios (p less than 0.05). The reduction in lactate in patients on valproate therapy may mask inborn errors of metabolism that normally result in an increase in blood lactate levels.
对10名患者一组进行了乳酸、丙酮酸和葡萄糖的测定。这些患者均患有癫痫症，分别接受苯妥英、丙戊酸、卡马西平或苯巴比妥的单一药物治疗，还有一些未服药的患者。所有药物水平均在治疗范围内。除苯妥英组患者年龄显著较大外，各组特征相似。葡萄糖或丙酮酸浓度未发现显著差异。然而，服用丙戊酸的患者乳酸水平降低（p<0.05），乳酸/丙酮酸比值降低（p<0.05）。丙戊酸盐治疗患者的乳酸水平降低可能掩盖了通常会导致血乳酸水平升高的先天性代谢缺陷。
