Nikolic Aleksandra, Djuric Sonja, Biocanin Vladimir, Djordjevic Katarina, Ravic Marko, Stojanovic Aleksandra, Milovanovic Olivera, Skerlic Jasmina, Pavlovic Radisa, Turnic Tamara Nikolic
Clinic for Rheumatology, Allergology and Clinical Immunology, Clinical Centre Kragujevac, Kragujevac, Serbia.
Gentext Research group, University of Valencia, Valencia, Spain.
Iran J Public Health. 2023 Jun;52(6):1181-1189. doi: 10.18502/ijph.v52i6.12960.
Elevated blood pressure (BP) is one of the leading causes for developing major cardiovascular events and still represents a major public health challenge worldwide. We aimed to provide data on predictors of poor adherence to medication in hypertensive patients in Serbia.
Observational, analytical study was undertaken at a group of 388 patients who refilled their medications in the Pharmacy Institution, "Apoteka Kragujevac", Kragujevac, Serbia between Jan and Mar 2019. Afterward, we conducted a case-control study to evaluate the influence of the variables associated with the adherence. We used a self-developed questionnaire and SF-36 to assess the influence of the quality of life on medication adherence.
Results revealed four independent predictors of non-adherence: increased number of medications, living in a city, forgetfulness of the dosing regimen and low energy. The odds of non-adherence were the highest among the participants living in the city and the low energy was the only factor inversely associated with the level of non-adherence.
Many factors were associated with the non-adherence to medication. Further studies are needed to find the most appropriate protocol to promote adherence. The four risk factors (increased number of medications, living in a city, forgetfulness of the dosing regimen and low energy) are associated with non-adherence in adult hypertensive patients.
血压升高是引发重大心血管事件的主要原因之一，在全球范围内仍是一项重大的公共卫生挑战。我们旨在提供塞尔维亚高血压患者药物治疗依从性差的预测因素的数据。
2019年1月至3月期间，在塞尔维亚克拉古耶瓦茨的“Apoteka Kragujevac”药房机构对388名补充药物的患者进行了观察性分析研究。之后，我们进行了一项病例对照研究，以评估与依从性相关变量的影响。我们使用自行编制的问卷和SF-36来评估生活质量对药物依从性的影响。
结果显示了四个不依从的独立预测因素：药物数量增加、居住在城市、忘记给药方案和精力不足。居住在城市的参与者不依从的几率最高，而精力不足是与不依从程度呈负相关的唯一因素。
许多因素与药物不依从有关。需要进一步研究以找到促进依从性的最合适方案。这四个风险因素（药物数量增加、居住在城市、忘记给药方案和精力不足）与成年高血压患者的不依从有关。
