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Diagnostic capacity for invasive fungal infections in advanced HIV disease in Africa: a continent-wide survey.在非洲晚期艾滋病患者中侵袭性真菌感染的诊断能力：一项全大陆范围的调查。
Lancet Infect Dis. 2023 May;23(5):598-608. doi: 10.1016/S1473-3099(22)00656-9. Epub 2022 Dec 21.
2
Drug-resistant fungi on the rise.耐药真菌正在增加。
Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2217948119. doi: 10.1073/pnas.2217948119. Epub 2022 Nov 21.
3
The research progress in the interaction between and cancers.[此处原文不完整，缺少关键内容]与癌症之间相互作用的研究进展。
Front Microbiol. 2022 Sep 28;13:988734. doi: 10.3389/fmicb.2022.988734. eCollection 2022.
4
Development and research progress of anti-drug resistant fungal drugs.抗耐药真菌药物的研发进展。
J Infect Public Health. 2022 Sep;15(9):986-1000. doi: 10.1016/j.jiph.2022.08.004. Epub 2022 Aug 10.
5
COVID-19-associated fungal infections.COVID-19 相关真菌感染。
Nat Microbiol. 2022 Aug;7(8):1127-1140. doi: 10.1038/s41564-022-01172-2. Epub 2022 Aug 2.
6
Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing.抗真菌药物研发进展：新药发现与药物再利用
Pharmaceuticals (Basel). 2022 Jun 24;15(7):787. doi: 10.3390/ph15070787.
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Overview of COVID-19-Associated Invasive Fungal Infection.新型冠状病毒肺炎相关侵袭性真菌感染概述
Curr Fungal Infect Rep. 2022;16(3):87-97. doi: 10.1007/s12281-022-00434-0. Epub 2022 Jul 11.
8
COVID-19-Associated Fungal Infections: An Urgent Need for Alternative Therapeutic Approach?新型冠状病毒肺炎相关真菌感染：是否迫切需要替代治疗方法？
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9
Pan-resistant Candida auris: New York subcluster susceptible to antifungal combinations.全耐药耳念珠菌：对抗真菌联合疗法敏感的纽约亚群
Lancet Microbe. 2020 Sep;1(5):e193-e194. doi: 10.1016/S2666-5247(20)30090-2. Epub 2020 Aug 3.
10
Tackling the emerging threat of antifungal resistance to human health.应对抗真菌耐药性对人类健康构成的新威胁。
Nat Rev Microbiol. 2022 Sep;20(9):557-571. doi: 10.1038/s41579-022-00720-1. Epub 2022 Mar 29.

新型取代单酰肼类高效抗真菌剂的发现与开发

Discovery and development of novel substituted monohydrazides as potent antifungal agents.

作者信息

Thamban Chandrika Nishad, Green Keith D, Spencer Abbygail C, Tsodikov Oleg V, Garneau-Tsodikova Sylvie

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536-0596 USA

出版信息

RSC Med Chem. 2023 Jun 14;14(7):1351-1361. doi: 10.1039/d3md00167a. eCollection 2023 Jul 20.

DOI:10.1039/d3md00167a
PMID:37484566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357949/
Abstract

Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.

摘要

为该研究合成的新型取代单酰肼对多种真菌菌株具有广谱活性，包括一组临床相关菌株。在大多数测试的真菌菌株中，这些化合物的活性与两性霉素B相当或优于两性霉素B。这些化合物在时间杀菌试验中具有抑菌活性，且对哺乳动物细胞无毒性。此外，它们还能防止真菌生物膜的形成。即使反复接触，ATCC 10231（菌株A）真菌菌株也未对这些单酰肼产生抗性。