Department of Pathology, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan.
The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung 82445 Taiwan.
Int J Med Sci. 2023 Jul 3;20(8):1091-1096. doi: 10.7150/ijms.84729. eCollection 2023.
Ficolin-3 (FCN3) is a well-known circulating pattern recognition molecule which plays a role in host immune responses to cancer via activation of the lectin complement pathway. Nevertheless, the clinical significance of FCN3 in patients with hepatocellular carcinoma (HCC) is unclear. Eighty-seven HCC patients who received hepatectomy at our hospital were included. Immunohistochemical staining was used to assess the FCN3 expression in both tumorous and non-tumorous tissues from the patients, who were classified into high and low expression groups. Differences in clinicopathological characteristics between the two groups were then analyzed. Survival was significantly associated with FCN3 immunohistochemical score (p for trend = 0.048). Kaplan-Meier analysis revealed a higher overall survival rate in the patients with a high FCN3 expression than in those with a low FCN3 expression (p=0.031). A high FCN3 expression in tumor tissue was independently associated with better overall survival (p=0.042). However, multivariate analysis showed that FCN3 expression was not an independent risk factor for overall survival. Our findings suggest that FCN3 is significantly related to the prognosis of HCC. FCN3 may be a prognostic marker in patients with HCC.
ficolin-3（FCN3）是一种众所周知的循环模式识别分子，通过激活凝集素补体途径在宿主对癌症的免疫反应中发挥作用。然而，FCN3 在肝细胞癌（HCC）患者中的临床意义尚不清楚。
本研究纳入了 87 例在我院接受肝切除术的 HCC 患者。采用免疫组织化学染色法检测患者肿瘤组织和非肿瘤组织中 FCN3 的表达，将其分为高表达组和低表达组。然后分析两组间的临床病理特征差异。
生存与 FCN3 免疫组织化学评分显著相关（趋势检验 p=0.048）。Kaplan-Meier 分析显示，FCN3 高表达组患者的总生存率高于 FCN3 低表达组（p=0.031）。肿瘤组织中 FCN3 的高表达与总生存率的提高独立相关（p=0.042）。然而，多因素分析显示 FCN3 表达不是总生存率的独立危险因素。
我们的研究结果表明，FCN3 与 HCC 的预后显著相关。FCN3 可能是 HCC 患者的预后标志物。
