患者报告结果测量信息系统（PROMIS）的身体功能和疼痛干扰评分与下肢多伦多肢体挽救评分相关。
PROMIS Physical Function and Pain Interference Scores Correlate with the Lower Extremity Toronto Extremity Salvage Score.
作者信息
Jin Julie, Hong Zachery, Rhea Lee, McDonald Douglas J, O'Keefe Regis J, Cipriano Cara A
机构信息
Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
出版信息
JB JS Open Access. 2023 Jul 21;8(3). doi: 10.2106/JBJS.OA.23.00011. eCollection 2023 Jul-Sep.
UNLABELLED
The Toronto Extremity Salvage Score (TESS) and the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) are both utilized to measure patient-reported outcomes in adults with musculoskeletal oncologic conditions. However, the relationship between them has not been studied. We sought to describe a link between Lower Extremity (LE) TESS and PROMIS Physical Function (PF) scores, as well as between LE TESS and Pain Interference (PI) scores, to develop a method for converting scores between TESS and PROMIS and to examine whether TESS and PROMIS captured differences in pain and function between clinically relevant subgroups in our population.
METHODS
Our study population consisted of 125 adult patients who underwent surgical treatment of a lower-extremity musculoskeletal tumor at a single sarcoma center between December 2015 and October 2018. The LE TESS questionnaire was administered to patients via paper and the PROMIS PF and PI were administered via iPad at a preoperative appointment. The relationship between LE TESS and PROMIS measures was analyzed with use of generalized linear modeling. Subgroup analyses were performed with a 2-tailed t test or 1-way analysis of variance.
RESULTS
PROMIS PF had a very strong positive correlation with LE TESS (r = 0.83) and was related through the following equation: = 0.00294 × () + 22.6. PROMIS PI had a strong negative correlation with LE TESS (r = -0.77) and was related through the following equation: = -0.00259 × () + 73.8. PROMIS PF and PI performed similarly to LE TESS across multiple patient subgroups and captured the expected differences between subgroups.
CONCLUSIONS
LE TESS and PROMIS PF appeared to measure similar information in patients with an orthopaedic oncologic condition. Moreover, PROMIS PI scores were strongly correlated with functional disability as measured with the LE TESS. Understanding the relationship between TESS and PROMIS will allow the comparison and combination of data for both clinical and research purposes.
LEVEL OF EVIDENCE
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
未标注
多伦多肢体挽救评分（TESS）和美国国立卫生研究院患者报告结局测量信息系统（PROMIS）均用于测量患有肌肉骨骼肿瘤疾病的成年人的患者报告结局。然而，它们之间的关系尚未得到研究。我们试图描述下肢（LE）TESS与PROMIS身体功能（PF）评分之间的联系，以及LE TESS与疼痛干扰（PI）评分之间的联系，以开发一种在TESS和PROMIS之间转换评分的方法，并检查TESS和PROMIS是否捕捉到了我们研究人群中临床相关亚组之间疼痛和功能的差异。
方法
我们的研究人群包括125名成年患者，他们于2015年12月至2018年10月在单个肉瘤中心接受了下肢肌肉骨骼肿瘤的手术治疗。LE TESS问卷通过纸质方式发给患者，PROMIS PF和PI在术前预约时通过iPad发给患者。使用广义线性模型分析LE TESS与PROMIS测量值之间的关系。亚组分析采用双尾t检验或单因素方差分析。
结果
PROMIS PF与LE TESS呈非常强的正相关（r = 0.83），并通过以下方程相关联：= 0.00294×（）+ 22.6。PROMIS PI与LE TESS呈强负相关（r = -0.77），并通过以下方程相关联：= -0.00259×（）+ 73.8。在多个患者亚组中，PROMIS PF和PI的表现与LE TESS相似，并捕捉到了亚组之间的预期差异。
结论
LE TESS和PROMIS PF似乎在骨科肿瘤疾病患者中测量了相似的信息。此外，PROMIS PI评分与用LE TESS测量的功能残疾密切相关。了解TESS和PROMIS之间的关系将有助于为临床和研究目的对数据进行比较和合并。
证据水平
预后III级。有关证据水平的完整描述，请参阅作者指南。
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