Oka Itsuhiro, Funayama Rie, Shimizu Hirotaka, Takeuchi Ichiro, Nojiri Shuko, Shimizu Toshiaki, Arai Katsuhiro
Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Pediatr Gastroenterol Hepatol Nutr. 2023 Jul;26(4):181-192. doi: 10.5223/pghn.2023.26.4.181. Epub 2023 Jul 5.
The development of assistive devices has allowed for the performance of capsule endoscopy in children. Anticipating the capsule's transit time could affect the efficacy of the investigation and potentially minimize the fasting period. This study determined the predictors of small bowel transit time for small-bowel capsule endoscopy in children and adolescents with inflammatory bowel disease.
We retrospectively examined children and adolescents with inflammatory bowel disease who underwent capsule endoscopy by the age 18 at a Japanese tertiary care children's hospital. Small bowel transit time predictors were analyzed using multiple regression with explanatory variables.
Overall, 92 patients, aged 1-17 years, with inflammatory bowel disease (63 Crohn's disease and 29 ulcerative colitis cases) were examined for factors affecting small bowel transit time. In the simple regression analysis, diagnosis, age, height, weight, serum albumin, general anesthesia, and small intestine lesions were significantly associated with small bowel transit time. In the multiple regression analyses, serum albumin (partial regression coefficient: -58.9, 0.008), general anesthesia (partial regression coefficient: 127, 0.001), and small intestine lesions (partial regression coefficient: 30.1, 0.037) showed significant associations with small bowel transit time.
Hypoalbuminemia, the use of general anesthesia for endoscopic delivery of the capsule, and small intestine lesions appeared to be predictors of prolonged small bowel transit time in children and adolescents with inflammatory bowel disease. Expecting the finishing time may improve examination with a fasting period reduction, which benefits both patients and caregivers.
辅助设备的发展使得儿童能够进行胶囊内镜检查。预测胶囊的通过时间可能会影响检查的效果，并有可能缩短禁食期。本研究确定了炎症性肠病儿童和青少年小肠胶囊内镜检查中小肠通过时间的预测因素。
我们回顾性研究了在日本一家三级儿童专科医院接受胶囊内镜检查的18岁及以下炎症性肠病儿童和青少年。使用具有解释变量的多元回归分析小肠通过时间的预测因素。
总体而言，对92例年龄在1至17岁的炎症性肠病患者（63例克罗恩病和29例溃疡性结肠炎病例）进行了影响小肠通过时间的因素检查。在简单回归分析中，诊断、年龄、身高、体重、血清白蛋白、全身麻醉和小肠病变与小肠通过时间显著相关。在多元回归分析中，血清白蛋白（偏回归系数：-58.9，P = 0.008）、全身麻醉（偏回归系数：127，P = 0.001）和小肠病变（偏回归系数：30.1，P = 0.037）与小肠通过时间显著相关。
低白蛋白血症、胶囊内镜检查时使用全身麻醉以及小肠病变似乎是炎症性肠病儿童和青少年小肠通过时间延长的预测因素。预计检查结束时间可能会在缩短禁食期的情况下改善检查效果，这对患者和护理人员都有益。
