Ji Kangfan, Yao Yuejun, Wei Xinwei, Liu Wei, Zhang Juan, Liu Yun, Zhang Yang, Wang Jinqiang, Gu Zhen
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.
Jinhua Institute of Zhejiang University, Jinhua, 321299 China.
Med X. 2023;1(1):7. doi: 10.1007/s44258-023-00006-y. Epub 2023 Jul 11.
Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are associated with low compliance. Accordingly, oral administration has been identified as a highly desirable alternative due to its non-invasive nature. However, the harsh gastrointestinal environment and physical intestinal barriers pose significant challenges to achieving optimal pharmacological bioavailability of insulin. As a result, researchers have developed a range of materials to improve the efficiency of oral insulin delivery over the past few decades. In this review, we summarize the latest advances in material design that aim to enhance insulin protection, permeability, and glucose-responsive release. We also explore the opportunities and challenges of using these materials for oral insulin delivery.
频繁注射胰岛素仍然是控制糖尿病患者血糖水平的主要方法，但存在依从性低的问题。因此，口服给药因其无创性而被视为一种非常理想的替代方法。然而，恶劣的胃肠道环境和肠道生理屏障对实现胰岛素的最佳药代动力学生物利用度构成了重大挑战。因此，在过去几十年里，研究人员开发了一系列材料来提高口服胰岛素递送的效率。在这篇综述中，我们总结了旨在增强胰岛素保护、渗透性和葡萄糖响应性释放的材料设计的最新进展。我们还探讨了使用这些材料进行口服胰岛素递送的机遇和挑战。
