BaSiON:Eu/聚二甲基硅氧烷复合弹性体的生物安全性评估

Biosafety evaluation of BaSiON:Eu/PDMS composite elastomers.

作者信息

Zhang Zheyuan, Zong Mingrui, Liu Jinrong, Ren Jianing, Liu Xiaoming, Zhang Ran, Cui Jiayu, Sun Lingxiang, Song Hao, Zhang Yanjie, Li Bing, Wu Xiuping

机构信息

School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, Shanxi, China.

Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, Shanxi, China.

出版信息

Front Bioeng Biotechnol. 2023 Jul 7;11:1226065. doi: 10.3389/fbioe.2023.1226065. eCollection 2023.

DOI:10.3389/fbioe.2023.1226065

PMID:37485317

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10360121/

Abstract

In recent years, mechanoluminescent (ML) materials have shown great potential in stress sensing, mechanical energy collection and conversion, so they have attracted wide attention in the field of stomatology. In the early stage of this study, BaSiON:Eu ML phosphors were synthesized by two-step high temperature solid state method, and then mixed with Polydimethylsiloxane (PDMS) in different proportions to obtain BaSiON:Eu/PDMS ML composites with different mass fractions (10%,20%,30%,40%,50%). Then its biosafety was evaluated by Cell Counting Kit-8 (CCK-8), Calcein-AM/PI fluorescence staining, hemolysis, oral mucosal irritation, acute and subacute systemic toxicity tests. The experimental results show that the biosafety of BaSiON:Eu/PDMS ML composite elastomers with different mass fraction is in line with the existing standards, and other related properties can be further studied.

摘要

近年来，机械发光（ML）材料在应力传感、机械能收集与转换方面展现出巨大潜力，因此在口腔医学领域受到广泛关注。在本研究前期，采用两步高温固相法合成了BaSiON:Eu ML荧光粉，然后将其与聚二甲基硅氧烷（PDMS）按不同比例混合，得到质量分数分别为10%、20%、30%、40%、50%的BaSiON:Eu/PDMS ML复合材料。随后，通过细胞计数试剂盒-8（CCK-8）、钙黄绿素-AM/PI荧光染色、溶血、口腔黏膜刺激、急性和亚急性全身毒性试验对其生物安全性进行评估。实验结果表明，不同质量分数的BaSiON:Eu/PDMS ML复合弹性体的生物安全性符合现有标准，其他相关性能可进一步研究。