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仿生珍珠母状陶瓷-聚合物复合材料的细胞毒性与粘结性能

Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites.

作者信息

Sun Hui, Gao Kefeng, Yi Zhe, Han Chengwei, Liu Zengqian, Wang Qiang, Zhou Qing, Zhang Zhefeng

机构信息

Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.

Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

出版信息

Front Bioeng Biotechnol. 2022 May 23;10:913899. doi: 10.3389/fbioe.2022.913899. eCollection 2022.

DOI:10.3389/fbioe.2022.913899
PMID:35677300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9168327/
Abstract

For clinical applications, non-cytotoxicity and good bonding property of dental restorative materials are the most essential and important. The aim of this study was to evaluate the potential for clinical applications of two novel bioinspired nacre-like ceramic (yttria-stabilized zirconia)-polymer (polymethyl methacrylate) composites in terms of the cytotoxicity and bonding property. The relative growth rates (24 h) of the Lamellar and Brick-and-mortar composites measured by CCK8 were 102.93%±0.04 and 98.91%±0.03, respectively. According to the results of cytotoxicity and proliferation experiments, the two composites were not cytotoxic to human periodontal ligament fibroblasts (HPDLFs) . Both composites exhibited improved bonding strength as compared to the Control group (Vita In-Ceram YZ). As the polymer content in the composite material increases, its bonding strength also increases, which enhances the application potential of the material in the field of dental restoration. Meanwhile, by controlling the direction of loading force in the shear test, the effect of microstructure on the bonding strength of anisotropic composites was studied. After sandblasted, the bonding strengths of the Lamellar group in the longitudinal and transverse shear directions were 17.56±1.56 MPa and 18.67±1.92 MPa, respectively, while of the Brick-and-mortar group were 16.36±1.30 MPa and 16.99±1.67 MPa, respectively. The results showed that the loading direction had no significant effect on the bonding strength of the composites.

摘要

对于临床应用而言，牙科修复材料的无细胞毒性和良好的粘结性能是最基本且重要的。本研究的目的是从细胞毒性和粘结性能方面评估两种新型仿生珍珠母状陶瓷（氧化钇稳定氧化锆）-聚合物（聚甲基丙烯酸甲酯）复合材料的临床应用潜力。通过CCK8测定的层状复合材料和砖灰浆状复合材料的相对生长率（24小时）分别为102.93%±0.04和98.91%±0.03。根据细胞毒性和增殖实验结果，这两种复合材料对人牙周膜成纤维细胞（HPDLFs）无细胞毒性。与对照组（维他全瓷YZ）相比，两种复合材料均表现出提高的粘结强度。随着复合材料中聚合物含量的增加，其粘结强度也增加，这增强了该材料在牙科修复领域的应用潜力。同时，通过在剪切试验中控制加载力的方向，研究了微观结构对各向异性复合材料粘结强度的影响。喷砂处理后，层状组在纵向和横向剪切方向的粘结强度分别为17.56±1.56MPa和18.67±1.92MPa，而砖灰浆组分别为16.36±1.30MPa和16.99±1.67MPa。结果表明，加载方向对复合材料的粘结强度没有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8e/9168327/a64c3e19c6c6/fbioe-10-913899-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8e/9168327/a64c3e19c6c6/fbioe-10-913899-g008.jpg

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