Biomedical Engineering Cockrell School of Engineering, the University of Texas at Austin, Austin, TX 78712, USA.
Biomedical Engineering Cockrell School of Engineering, the University of Texas at Austin, Austin, TX 78712, USA.
Adv Drug Deliv Rev. 2022 Jul;186:114343. doi: 10.1016/j.addr.2022.114343. Epub 2022 May 15.
Ultrasound induced organic mechanoluminescence materials have become one of the focal topics in wireless light sources since they exhibit high spatiotemporal resolution, biocompatibility and excellent tissue penetration depth. These properties promote great potential in ultrahigh sensitive bioimaging with no background noise and noninvasive nanodevices. Recent advances in chemistry, nanotechnology and biomedical research are revolutionizing ultrasound induced organic mechanoluminescence. Herein, we try to summarize some recent researches in ultrasound induced mechanoluminescence that use various materials design strategies based on the molecular conformational changes and cycloreversion reaction. Practical applications, like noninvasive bioimaging and noninvasive optogenetics, are also presented and prospected.
超声致动的有机力致发光材料因其具有高时空分辨率、生物相容性和优异的组织穿透深度，已成为无线光源的研究热点之一。这些特性在超高灵敏度生物成像中具有巨大的应用潜力，可实现无背景噪声和非侵入性的纳米器件。化学、纳米技术和生物医学研究的最新进展正在彻底改变超声致动的有机力致发光。本文尝试总结了一些基于分子构象变化和环反转反应的各种材料设计策略的超声致动机理发光的最新研究，并介绍和展望了其在无创生物成像和无创光遗传学等实际应用方面的发展前景。
