Zhang Meng-Meng, Hu Yan, Xu Jing, Liu Ling, Lv Lu-Lu
Turk J Gastroenterol. 2023 Aug;34(8):782-794. doi: 10.5152/tjg.2023.23137.
Gastrointestinal diseases are highly prevalent, and their burden significantly impacts the quality of life of affected individuals. Inflammatory and immune-mediated intestinal diseases usually have a chronic course without adequate therapeutic modalities. Although much has been reported to comprehend these diseases, many remain resistant and refractory to conventional treatment approaches. Therefore, recent approaches to cellular therapy using stem cells, like hematopoietic stem cells and mesenchymal stem cells, and other cellular immunosuppressive modalities, like T-regulatory cells, were introduced and investigated in treating gastrointestinal diseases. We aimed to conduct a literature review to discuss the applications and challenges of cellular therapeutics in gastrointestinal diseases. Evidence from published clinical trials supports the safety and efficacy of cellular treatment in different immune-mediated and inflammatory gastrointestinal diseases. They can offer a longer duration of remission, being able to adjust the dysregulated immune system. However, there are various challenges to be considered by future trials, including the limitations of current clinical trials, challenges in retrieval and application of these therapeutics, and their mutagenesis potential.
胃肠道疾病非常普遍，其负担严重影响患者的生活质量。炎症和免疫介导的肠道疾病通常病程慢性，且缺乏足够的治疗方法。尽管已经有很多关于这些疾病的报道，但许多疾病对传统治疗方法仍然耐药且难治。因此，最近引入了使用干细胞（如造血干细胞和间充质干细胞）的细胞治疗方法以及其他细胞免疫抑制方法（如调节性T细胞）来治疗胃肠道疾病，并对其进行了研究。我们旨在进行一项文献综述，以讨论细胞疗法在胃肠道疾病中的应用和挑战。已发表的临床试验证据支持细胞治疗在不同免疫介导和炎症性胃肠道疾病中的安全性和有效性。它们可以提供更长的缓解期，能够调节失调的免疫系统。然而，未来的试验需要考虑各种挑战，包括当前临床试验的局限性、这些治疗方法的获取和应用方面的挑战以及它们的诱变潜力。
