Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan, 430062, P. R. China.
School of Health Science & Biomedical Engineering, Hebei University of Technology, Xiping Avenue 5340, Beichen District, Tianjin, 300401, P. R. China.
Small. 2023 Nov;19(47):e2303484. doi: 10.1002/smll.202303484. Epub 2023 Jul 23.
The ability to effectively treat deep bacterial infections while promoting osteogenesis is the biggest treatment demand for diseases such as osteomyelitis. Microwave therapy is widely studied due to its remarkable ability to penetrate deep tissue. This paper focuses on the development of a microwave-responsive system, namely, a zinc ion (Zn ) doped graphite carbon nitride (CN) system (BZCN), achieved through two high-temperature burning processes. By subjecting composite materials to microwave irradiation, an impressive 99.81% eradication of Staphylococcus aureus is observed within 15 min. Moreover, this treatment enhances the growth of bone marrow stromal cells. The Zn doping effectively alters the electronic structure of CN, resulting in the generation of a substantial number of free electrons on the material's surface. Under microwave stimulation, sodium ions collide and ionize with the free electrons generated by BZCN, generating a large amount of energy, which reacts with water and oxygen, producing reactive oxygen species. In addition, Zn doping improves the conductivity of CN and increases the number of unsaturated electrons. Under microwave irradiation, polar molecules undergo movement and generate frictional heat. Finally, the released Zn promotes macrophages to polarize toward the M2 phenotype, which is beneficial for tibial repair.
有效治疗深部细菌感染并促进成骨是骨髓炎等疾病的最大治疗需求。微波治疗因其能显著穿透深部组织而被广泛研究。本文专注于开发一种微波响应系统，即通过两个高温燃烧过程实现的锌离子（Zn ）掺杂石墨碳氮化物（CN）系统（BZCN）。通过对复合材料进行微波照射，在 15 分钟内可实现对金黄色葡萄球菌的 99.81%的消除。此外，这种治疗方法还能促进骨髓基质细胞的生长。Zn 掺杂能有效改变 CN 的电子结构，在材料表面产生大量自由电子。在微波刺激下，钠离子与 BZCN 产生的自由电子发生碰撞和电离，产生大量能量，与水和氧气反应生成活性氧物质。此外，Zn 掺杂能提高 CN 的导电性并增加不饱和电子的数量。在微波照射下，极性分子发生运动并产生摩擦热。最后，释放的 Zn 促进巨噬细胞向 M2 表型极化，这有利于胫骨修复。
