Birkner Thomas, Siegels Doreen, Heinrich Luise, Haufe Eva, Abraham Susanne, Heratizadeh Annice, Harder Inken, Bell Magnus, Fell Isabell, Worm Margitta, Handrick Christiane, Effendy Isaak, Asmussen Andrea, Kleinheinz Andreas, Homey Bernhard, Sticherling Michael, Hong-Weldemann Sung-Hei, Augustin Matthias, Weisshaar Elke, Schäkel Knut, Schaefer Thomas, Schwarz Beate, Wiemers Franca, Brücher Jens-Joachim, Quist Sven, Wollenberg Andreas, Biedermann Tilo, Ertner Konstantin, von Kiedrowski Ralph, Werfel Thomas, Weidinger Stephan, Schmitt Jochen
Center of Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Department of Dermatology, University Allergy Center, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
J Dtsch Dermatol Ges. 2023 Oct;21(10):1157-1168. doi: 10.1111/ddg.15159. Epub 2023 Jul 23.
TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.
In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.
The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).
The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.
TREATgermany是一个多中心登记处，纳入了来自德国目前74个研究中心（大学诊所、医院和医疗机构）的中重度特应性皮炎（AD）患者。截至2021年8月31日，共招募了1230名成年患者。
在TREATgermany中，患者和医生填写有关症状、疾病严重程度、生活质量、抑郁和疲劳的问卷。特别是，使用工作限制问卷（WLQ）评估工作表现的限制。为了评估职业表现/工作限制与症状之间的关联，计算了相关性和回归模型。
在登记处登记前的过去两周内，所调查的228名在职患者样本报告平均工作效率损失6%。WLQ工作效率损失评分与瘙痒（r = 0.32）和睡眠损失（r = 0.39）中度相关，与抑郁症状（r = 0.68）和疲劳（r = 0.60）高度相关。
登记处数据分析表明，中重度特应性皮炎对患者的工作效率有负面影响。分析还进一步指出了工作效率、抑郁症状和疲劳之间的相关关联，突出了AD心理因素所造成的疾病负担。
