Occupational Dermatology, Department of Dermatology, University of Heidelberg.
Institute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Magdeburg, Germany; Institute for Epidemiology and Preventive Medicine/Medical Sociology, University of Regensburg, Regensburg, Germany.
Acta Derm Venereol. 2023 Jan 23;103:adv00854. doi: 10.2340/actadv.v103.4426.
TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.
TREATgermany 是一项由研究者发起的前瞻性疾病登记研究。它调查了医生和患者报告的疾病严重程度（湿疹面积和严重程度指数（EASI）、客观特应性皮炎评分（oSCORAD）、研究者整体评估、患者导向的湿疹量表（POEM）、患者整体评估（PGA））、患者报告的症状（瘙痒、睡眠损失、抑郁症状）、治疗过程和中重度特应性皮炎的皮肤病生活质量（DLQI），SCORAD>20。1134 名特应性皮炎患者（平均年龄 41.0±14.7 岁，42.5%为女性）于 2016 年 6 月至 2021 年 4 月期间由 40 个德国招募点（皮肤科诊所和实践）纳入该研究。目前的分析重点是基线就诊前 3 天内用数字评分量表（NRS）记录的瘙痒评分。结果显示，97.2%（1121 例中的 1090 例）患者有瘙痒。瘙痒严重程度与特应性皮炎 oSCORAD（rho=0.44（0.39-0.48））和 EASI 评分（rho=0.41（0.36-0.46））中度相关。与自我报告的疾病严重程度（PGA，rho=0.68（0.65-0.71））、POEM 总分（rho=0.66（0.63-0.69））和皮肤病生活质量受损 DLQI（rho=0.61（0.57-0.65））的相关性较强。作为一种主观抱怨，瘙痒与患者报告的结局比与医生的客观评估更为密切相关。
