Lyu Jia-Ling, Wu Po-Yuan, Liao Hsiao-Fang, Lee Chia-Lin, Wen Kuo-Ching, Chang Chang-Cheng, Chiang Hsiu-Mei
Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan.
School of Medicine, China Medical University, Taichung 404, Taiwan.
Molecules. 2025 Jul 31;30(15):3209. doi: 10.3390/molecules30153209.
Photoaging, predominantly induced by ultraviolet radiation, is a primary driver of premature skin aging, characterized by complex molecular mechanisms including oxidative stress, inflammation, matrix metalloproteinase activation, and extracellular matrix degradation. Consequently, there is growing scientific interest in identifying effective natural agents to counteract skin aging and photoaging. Djulis (), an indigenous Taiwanese pseudocereal from the Amaranthaceae family, has emerged as a promising candidate for skincare applications because of its rich phytochemicals and diverse bioactivities. This review describes the current understanding of the molecular mechanisms underlying photoaging and examines the therapeutic potential of djulis extract as a multifunctional agent for skin aging. Its mechanisms of action include enhancing antioxidant defenses, modulating inflammatory pathways, preserving the extracellular matrix, and inhibiting the formation of advanced glycation end products. Bioactive constituents of djulis extract, including phenolic compounds, flavonoids, and betanin, are known to exhibit potent antioxidant and photoprotective activities by modulating multiple molecular pathways essential for skin protection. The bioactivities of djulis in in vitro and animal studies, and four skin clinical trials of djulis extract products are presented in this review article. Ultimately, this review provides an overview that supports the potential of djulis extract in the development of evidence-based skincare formulations for the prevention and treatment of skin aging.
光老化主要由紫外线辐射引起，是皮肤过早老化的主要驱动因素，其特征在于包括氧化应激、炎症、基质金属蛋白酶激活和细胞外基质降解在内的复杂分子机制。因此，越来越多的科学研究致力于寻找有效的天然物质来对抗皮肤老化和光老化。杜利斯（Djulis）是一种来自苋科的台湾本土伪谷物，由于其丰富的植物化学物质和多样的生物活性，已成为护肤品应用的一个有前景的候选物。这篇综述描述了目前对光老化潜在分子机制的理解，并探讨了杜利斯提取物作为一种多功能抗皮肤老化剂的治疗潜力。其作用机制包括增强抗氧化防御、调节炎症途径、保护细胞外基质以及抑制晚期糖基化终产物的形成。已知杜利斯提取物的生物活性成分，包括酚类化合物、黄酮类化合物和甜菜红素，通过调节对皮肤保护至关重要的多种分子途径，表现出强大的抗氧化和光保护活性。本文综述了杜利斯在体外和动物研究中的生物活性，以及四项杜利斯提取物产品的皮肤临床试验。最终，本综述提供了一个概述，支持杜利斯提取物在开发用于预防和治疗皮肤老化的循证护肤配方方面的潜力。
