National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China.
ACS Appl Mater Interfaces. 2023 Aug 9;15(31):37232-37246. doi: 10.1021/acsami.3c06430. Epub 2023 Jul 24.
Poly(etheretherketone) (PEEK) is regarded as an attractive orthopedic material because of its good biocompatibility and mechanical properties similar to natural bone. The efficient activation methods for the surfaces of PEEK matrix materials have become a hot research topic. In this study, a method using a femtosecond laser (FSL) followed by hydroxylation was developed to achieve efficient bioactivity. It produces microstructures, amorphous carbon, and grafted -OH groups on the PEEK surface to enhance hydrophilicity and surface energy. Both experimental and simulation results show that our modification leads to a superior ability to induce apatite deposition on the PEEK surface. The results also demonstrate that efficient grafting of C-OH through FSL-hydroxylation can effectively enhance cell proliferation and osteogenic differentiation compared to other modifications, thus improving osteogenic activity. Overall, FSL hydroxylation treatment is proved to be a simple, efficient, and environmentally friendly modification method for PEEK activation. It could expand the applications of PEEK in orthopedics, as well as promote the surface modification and structural design of other polymeric biomaterials to enhance bioactivity.
聚醚醚酮（PEEK）因其良好的生物相容性和与天然骨相似的机械性能而被视为一种有吸引力的骨科材料。PEEK 基体材料表面的高效活化方法已成为研究热点。本研究采用飞秒激光（FSL）后羟化的方法实现了高效的生物活性。它在 PEEK 表面产生微观结构、非晶碳和接枝的-OH 基团，以提高亲水性和表面能。实验和模拟结果均表明，我们的改性可显著提高 PEEK 表面诱导磷灰石沉积的能力。结果还表明，与其他改性方法相比，通过 FSL-羟化有效接枝 C-OH 可有效促进细胞增殖和成骨分化，从而提高成骨活性。总之，FSL 羟化处理被证明是一种简单、高效、环保的 PEEK 活化改性方法。它可以扩展 PEEK 在骨科中的应用，并促进其他聚合物生物材料的表面改性和结构设计，以提高生物活性。
