Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cell Mol Med. 2023 Aug;27(16):2278-2289. doi: 10.1111/jcmm.17875. Epub 2023 Jul 24.
MIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.
MIR100HG 是一种长链非编码 RNA（lncRNA），由 chr11:122,028,203-122,556,721 上的一个基因座编码。该基因可调节细胞增殖、凋亡、细胞周期转变和细胞分化。MIR100HG 最初是通过转录组分析鉴定出来的，可调节人神经干细胞的分化。它与 TGF-β、Wnt、Hippo 和 ERK/MAPK 信号通路等多种信号通路功能相关。在多种癌症中均检测到 MIR100HG 的失调与临床结局相关。此外，它在扩张型心肌病、椎间盘退变和肺纤维化的病理生理学中发挥作用。本研究总结了这些 lncRNA 在人类疾病中的作用。
