Facile and efficient preparation of amino bearing metal-organic frameworks-coated cotton fibers for solid-phase extraction of non-steroidal anti-inflammatory drugs in human plasma.

The determination of blood concentration of non-steroidal anti-inflammatory drugs (NSAIDs) is highly desired in clinical practice. In this work, three amino bearing metal-organic frameworks (amino-MOFs) coated cotton fibers were prepared using a facile cysteine-triggered in situ growth strategy and proposed as in-tip solid-phase microextraction (in-SPME) adsorbents for efficient extraction of non-steroidal anti-inflammatory drugs from human plasma. The self-made adsorbents exhibited satisfactory extraction performance toward three NSAIDs including diclofenac sodium, ketoprofen and flurbiprofen. Under the optimized conditions, the established method exhibited satisfactory enrichment performance, low limits of detection and excellent extraction efficiency. Good reproducibility, wide linear range, excellent linearity and satisfactory sensitivity were obtained in the experiment. The method was also used for the enrichment and determination of NSAIDs in human plasma samples. Good recoveries were obtained, ranging from 66.5% to 98.9% with relative standard deviations less than 6.62%. The good performance of amino-MOFs was due to the synergistic effects arising from grafted charged amino groups within ordered pores of suitable size, leading to strong affinity towards guest molecules. Electrostatic interaction, hydrogen bond and π-π interaction played a vital role in the extraction of NSAIDs. This report indicated the potential of amino-MOFs as efficient adsorbents for the determination of NSAIDs from human plasma.