Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Beijing Center of AGRI-Products Quality and Safety, Beijing 100029, China.
Food Chem. 2023 Dec 15;429:136944. doi: 10.1016/j.foodchem.2023.136944. Epub 2023 Jul 19.
Mycotoxins are toxic metabolites produced by fungi in the process of infecting agricultural products, posing serious threat to the health of human and animals. Thus, sensitive and reliable analytical techniques for mycotoxin detection are needed. Biosensors equipped with antibodies or aptamers as recognition elements and core-shell nanoparticles (NPs) for the pre-treatment and detection of mycotoxins have been extensively studied. By comparison with monocomponent NPs, core-shell nanostructures exhibit unique optical, electric, magnetic, plasmonic, and catalytic properties due to the combination of functionalities and synergistic effects, resulting in significant improvement of sensing capacities in various platforms, such as surface-enhanced Raman spectroscopy, fluorescence, lateral flow immunoassay and electrochemical sensors. This review focused on the development of core-shell NPs based biosensors for the sensitive and accurate detection of mycotoxins in food samples. Recent developments were categorised and summarised, along with detailed discussion of advantages and shortcomings. The future potential of utilising core-shell NPs in food safety testing was also highlighted.
真菌在侵染农产品的过程中会产生有毒的代谢物，即霉菌毒素，这些毒素对人类和动物的健康构成了严重威胁。因此，需要灵敏可靠的霉菌毒素检测分析技术。基于抗体或适体作为识别元件、核壳纳米颗粒（NPs）用于霉菌毒素预处理和检测的生物传感器已经得到了广泛的研究。与单一组分的 NPs 相比，核壳纳米结构由于功能的结合和协同作用而表现出独特的光学、电学、磁学、等离子体和催化特性，从而在各种平台（如表面增强拉曼光谱、荧光、侧向流动免疫分析和电化学传感器）中显著提高了传感能力。本综述重点介绍了基于核壳 NPs 的生物传感器在食品样品中灵敏、准确检测霉菌毒素方面的发展。对近年来的研究进展进行了分类和总结，并详细讨论了各自的优缺点。同时还强调了核壳 NPs 在食品安全检测中的应用潜力。
