Human Technopole, Milan, Italy.
Institute of Molecular Systems Biology, ETH Zürich, Zurich, Switzerland.
FEBS Lett. 2023 Aug;597(15):1921-1927. doi: 10.1002/1873-3468.14699. Epub 2023 Jul 24.
The systematic identification of tumour vulnerabilities through perturbational experiments on cancer models, including genome editing and drug screens, is playing a crucial role in combating cancer. This collective effort is known as the Cancer Dependency Map (DepMap). The 1st European Cancer Dependency Map Symposium (EuroDepMap), held in Milan last May, featured talks, a roundtable discussion, and a poster session, showcasing the latest discoveries and future challenges related to the DepMap. The symposium aimed to facilitate interactions among participants across Europe, encourage idea exchange with leading experts, and present their work and future projects. Importantly, it sparked discussions on future endeavours, such as screening more complex cancer models and accounting for tumour evolution.
通过对癌症模型（包括基因组编辑和药物筛选）进行扰动实验，系统性地鉴定肿瘤弱点，在抗击癌症方面发挥着至关重要的作用。这一集体努力被称为癌症依赖性图谱（DepMap）。去年 5 月在米兰举行的第一届欧洲癌症依赖性图谱研讨会（EuroDepMap）上，与会者进行了演讲、圆桌讨论和海报展示，介绍了与 DepMap 相关的最新发现和未来挑战。该研讨会旨在促进欧洲各地参与者之间的互动，鼓励与领先专家交流想法，并展示他们的工作和未来项目。重要的是，它还讨论了未来的努力方向，例如筛选更复杂的癌症模型和考虑肿瘤进化。
