Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Trends Microbiol. 2023 Dec;31(12):1238-1250. doi: 10.1016/j.tim.2023.06.007. Epub 2023 Jul 22.
Acinetobacter baumannii is a Gram-negative opportunistic bacterium responsible for nosocomial and community-acquired infections. This pathogen is globally disseminated and associated with high levels of antibiotic resistance, which makes it an important threat to human health. Recently, new evidence showed that several A. baumannii isolates can survive and proliferate within eukaryotic professional and/or nonprofessional phagocytic cells, with in vivo consequences. This review provides updated information and describes the tools that A. baumannii possesses to adhere, colonize, and replicate in host cells. Additionally, we emphasize the high genetic and phenotypic heterogeneity detected amongst A. baumannii isolates and its impact on the bacterial intracellular features. We also discuss the need for standardized methods to characterize this pathogen robustly and consequently consider some strains as facultative intracellular bacteria.
鲍曼不动杆菌是一种革兰氏阴性机会致病菌，可导致医院获得性和社区获得性感染。这种病原体在全球范围内传播，并具有高水平的抗生素耐药性，因此对人类健康构成了重大威胁。最近的新证据表明，一些鲍曼不动杆菌分离株可以在真核专业和/或非专业吞噬细胞内存活和增殖，并产生体内后果。本综述提供了更新的信息，并描述了鲍曼不动杆菌在宿主细胞中黏附、定植和复制所具备的工具。此外，我们强调了在鲍曼不动杆菌分离株中检测到的高遗传和表型异质性及其对细菌细胞内特征的影响。我们还讨论了需要标准化的方法来对这种病原体进行稳健的特征描述，并因此将一些菌株视为兼性细胞内细菌。
