Liang Danyan, Liu Wei, Zhong Yao, Yang Jun, Chen Lulin
The Second Nanning People's Hospital, Nanning, People's Republic of China.
Guangxi University of Science and Technology, Liuzhou, People's Republic of China.
BMC Infect Dis. 2025 Jun 2;25(1):783. doi: 10.1186/s12879-025-11173-1.
Healthcare-associated infections (HAIs), which are associated with prolonged hospitalization and increased mortality, remain a global challenge. The COVID-19 pandemic paradoxically reduced some HAIs through enhanced hygiene measures but exacerbated others due to resource diversion, with effects after policy changes remaining unclear. Therefore, this study analyzed HAIs distribution, pathogenic microorganisms distribution, and antibiotic susceptibility capturing the period surrounding strict COVID-19 control measures in a southwest China tertiary hospital.
We conducted a retrospective study at a tertiary hospital in southwest China from 2019 to 2023. Data were extracted from real-time surveillance system, where HAIs were initially diagnosed by clinicians and subsequently verified by infection control personnel. The HAI incidence rate was calculated per 1000 hospital stays, and negative-binomial regression was used to compare incidence rates across years.
This study enrolled 2808 HAI cases, with 1665 males and 1143 females, averaging 61.37 years old. The incidence rates of HAIs from 2019 to 2023 were 1.75, 1.12, 0.98, 1.31, and 1.30 per 1000 hospital stays, respectively. Hematology (323, 11.50%), cardiology (309, 11.00%), and neurology (262, 9.33%) were the top three departments with the highest HAI rates. Lower respiratory tract (1198, 42.66%), bloodstream (419, 14.92%), and urinary tract (406, 14.46%) were the most common HAI sites. Klebsiella pneumoniae (173, 15.22%), Escherichia coli (155, 13.63%), and Acinetobacter baumannii (136, 11.96%) were the most frequent pathogenic microorganism. Acinetobacter baumannii was resistant to most antibiotics. Klebsiella pneumoniae was most resistant to cefuroxime Axetil, cefuroxime and ceftriaxone. Escherichia coli was most resistant to sulfamethoxazole and trimethoprim, ceftriaxone and cefuroxime. These three pathogenic microorganisms were all susceptible to tigecycline.
The incidence rates of HAIs fluctuated over the years, peaking in 2019, suggesting potential shifts in infection control dynamics. Klebsiella pneumoniae, Escherichia coli, and Acinetobacter baumannii were the predominant pathogens, and tigecycline may be considered as a potential option against these pathogens. The study highlights the importance of enhancing infection control measures in high-risk departments and sites, optimizing antibiotic stewardship, and continuously monitoring HAI trends to inform evidence-based infection control policies.
Not applicable.
医疗保健相关感染（HAIs）与住院时间延长和死亡率增加相关，仍然是一项全球性挑战。矛盾的是，新冠疫情通过加强卫生措施减少了一些HAIs，但由于资源转移又加剧了其他HAIs，政策变化后的影响仍不明确。因此，本研究分析了中国西南部一家三级医院在严格的新冠疫情防控措施前后这段时间内HAIs的分布、致病微生物分布及抗生素敏感性。
我们对中国西南部一家三级医院2019年至2023年进行了一项回顾性研究。数据从实时监测系统中提取，HAIs最初由临床医生诊断，随后由感染控制人员进行核实。每1000次住院计算HAIs发病率，并使用负二项回归比较各年份的发病率。
本研究纳入了2808例HAIs病例，其中男性1665例，女性1143例，平均年龄61.37岁。2019年至2023年每1000次住院的HAIs发病率分别为1.75、1.12、0.98、1.31和1.30。血液科（323例，11.50%）、心内科（309例，11.00%）和神经内科（262例，9.33%）是HAIs发生率最高的前三个科室。下呼吸道（1198例，42.66%）、血流（419例，14.92%）和泌尿道（406例，14.46%）是最常见的HAIs部位。肺炎克雷伯菌（173例，15.22%）、大肠埃希菌（155例，13.63%）和鲍曼不动杆菌（136例，11.96%）是最常见的致病微生物。鲍曼不动杆菌对大多数抗生素耐药。肺炎克雷伯菌对头孢呋辛酯、头孢呋辛和头孢曲松耐药性最强。大肠埃希菌对复方磺胺甲恶唑、头孢曲松和头孢呋辛耐药性最强。这三种致病微生物均对替加环素敏感。
多年来HAIs发病率波动，2019年达到峰值，提示感染控制动态可能发生了变化。肺炎克雷伯菌、大肠埃希菌和鲍曼不动杆菌是主要病原体，替加环素可被视为针对这些病原体的潜在选择。该研究强调了加强高危科室和部位的感染控制措施、优化抗生素管理以及持续监测HAIs趋势以制定循证感染控制政策的重要性。
不适用。
