Central Laboratory, The Second Hospital of Jilin University, Changchun, China.
Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, China.
Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188959. doi: 10.1016/j.bbcan.2023.188959. Epub 2023 Jul 22.
More recently, microbiota was detected in several tumorous tissues including multiple myeloma (MM), but the roles of which is still under-studied as paucity of research on tumor biology. Moreover, we also detected the presence of microbiota in the bone marrow of patients with MM by 2bRAD-M sequencing technology, which is an incurable hematological malignancy characterized by accumulation of abnormal plasma cells in the bone marrow. However, the roles of intratumor microbiota in tumor disease remains poorly understood. In this review, we critically reviewed recent literature about microbiota in the tumorigenesis and progression of MM. Importantly, we proposed that the emergence of microbiota in the microenvironment of multiple myeloma may be attributed to microbial dysbiosis and impaired intestinal barrier, due to the increased prevalence of MM in patients with obesity and diabetes, of which the characteristic phenotype is gut microbial dysbiosis and impaired intestinal barrier. When the intestinal barrier is damaged, dysbiotic microbiota and their metabolites, as well as dysregulated immune cells, may participate in the reshaping of the local immune microenvironment, and play pivotal roles in the tumorigenesis and development of multiple myeloma, probably by migrating to the bone marrow microenvironment from intestine. We also discuss the emerging microbiological manipulation strategies to improve long-term outcomes of MM, as well as the prospective of the state-of-the-art techniques to advance our knowledge about the biological implication in the microbiome in MM.
最近，在包括多发性骨髓瘤（MM）在内的几种肿瘤组织中也检测到了微生物群，但由于对肿瘤生物学的研究较少，其作用仍在研究中。此外，我们还通过 2bRAD-M 测序技术检测到 MM 患者骨髓中存在微生物群，多发性骨髓瘤是一种不可治愈的血液恶性肿瘤，其特征是骨髓中异常浆细胞的积累。然而，肿瘤内微生物群在肿瘤疾病中的作用仍知之甚少。在这篇综述中，我们批判性地回顾了关于微生物群在 MM 肿瘤发生和进展中的最新文献。重要的是，我们提出，微生物群在多发性骨髓瘤微环境中的出现可能归因于微生物失调和肠道屏障受损，因为肥胖和糖尿病患者多发性骨髓瘤的患病率增加，其特征表型是肠道微生物失调和肠道屏障受损。当肠道屏障受损时，失调的微生物群及其代谢物以及失调的免疫细胞可能参与重塑局部免疫微环境，并在多发性骨髓瘤的肿瘤发生和发展中发挥关键作用，可能通过从肠道迁移到骨髓微环境。我们还讨论了新兴的微生物操纵策略，以改善 MM 的长期预后，以及最先进技术的前景，以提高我们对 MM 微生物组生物学意义的认识。
