铁死亡作为癌症治疗的一个潜在靶点。

Department of Gastroenterology, the Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Tumor Molecular Therapy Medicine, Xinxiang, 453003, Henan Province, China.

Department of Biomedical Science, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam 13200, Kepala Batas, Pulau Pinang, Malaysia.

Cell Death Dis. 2023 Jul 24;14(7):460. doi: 10.1038/s41419-023-05930-w.

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.

铁死亡是一种新近发现的细胞死亡方式，主要特征为铁过载和脂质过氧化。有研究表明，铁死亡在人类癌症中是一把双刃剑。然而，其在肿瘤发生发展中的确切分子机制及其差异尚不清楚。因此，在这篇综述中，我们总结并简要介绍了铁死亡的关键途径，特别关注铁死亡的调控及其在各种人类癌症中作为致癌和抑癌事件的双重作用。此外，我们还总结了多种铁死亡激活剂，并进一步阐述了针对铁死亡在癌症治疗中的应用前景。